Jim Hoffman: Thrombomodulin as a Key Regulator of Coagulation and Inflammation
Jim Hoffman, Former Technical Advisor at Cygnus Technologies, LLC, shared a post on LinkedIn about an article by Yasuyo Shimomura et al. published in Journal of Intensive Care, adding:
“Thrombomodulin (TM) is a protein that plays a crucial role in regulating coagulation and inflammation.
It is primarily expressed on the cell surface of endothelial cells, but its soluble form exists in the circulation as well.
TM, when optimally dosed, has been demonstrated to exert a protective effect against greater endothelial dysfunction and vascular damage during experimental sepsis and coagulopathy.
Recombinant human-soluble TM (rTM) administration has been used in humans, primarily in Japan, for the treatment of sepsis and hematological malignancy-associated disseminated intravascular coagulation DIC, reducing the severity of vascular injury since 2008.
In the context of dysregulated NETosis, which is also prevalent DIC progression, resulting in greater vascular injury, TM is known to inhibit platelet and LPS-facilitated NETosis induction in vitro.
Based on the work of Toh et al., and the enlightening research of many other NETosis investigators; NETosis dysregulation should be directly targeted by extracorporeal depletion therapy to reduce DIC severity and reduce the risk of life-threatening immunothrombotic ischemic events.
NETosis induction and impaired chromatin/NET clearance from the blood positively correlate with an increased risk of life-threatening disseminated intravascular coagulation and ischemic circulatory failure events.”
Title: Recombinant human thrombomodulin inhibits neutrophil extracellular trap formation in vitro
Authors: Yasuyo Shimomura, Mika Suga, Naohide Kuriyama, Tomoyuki Nakamura, Toshikazu Sakai, Yu Kato, Yoshitaka Hara, Chizuru Yamashita, Hiroshi Nagasaki, Masao Kaneki, Osamu Nishida
Stay updated on all scientific advances Hemostasis Today.
-
May 12, 2026, 16:46Tagreed Alkaltham: Why Apheresis Matters in Modern Transfusion Medicine
-
May 12, 2026, 16:37Reinhold Kreutz: Cardiovascular Burden in Acute Intermittent Porphyria Needs Greater Awareness
-
May 12, 2026, 16:33Pablo Corral: The Truth About Very Low LDL-Cholesterol
-
May 12, 2026, 16:24Mildred Lundgren: We Must Talk About the Invisible Causes of Stroke
-
May 12, 2026, 16:17Irene Scala: The Sex Disparities In Access to Acute Stroke Treatments In Italy
-
May 12, 2026, 16:04May Nour: UCLA Health Mobile Stroke Unit Becomes The 1st In The World to Perform mCTA In the Field
-
May 12, 2026, 15:57Leonardo Roever: Prognostic Impact of Lipoprotein(a) and CAR in Elderly Acute Ischemic Stroke Patients
-
May 12, 2026, 15:54Bruno Pougault: Prioritizing Laboratory Tests in Resource-Limited Emergency Care
-
May 12, 2026, 15:37Jennifer Holter Chakrabarty: Supporting the Next Generation of Hematology Researchers