Wolfgang Miesbach: A New Genetic Perspective on the Worldwide Burden of von Willebrand Disease
Wolfgang Miesbach, Professor of Medicine at Frankfurt University Hospital, shared on LinkedIn about a recent article by Omid Seidizadeh et al, published in Nature Scientific Reports, adding:
”How common is von Willebrand disease?
Far more prevalent than registries indicate.
A new Nature study uses gnomAD v4.1 (807,000+ sequenced individuals) and Hardy–Weinberg genetic modeling on 321 pathogenic/likely pathogenic VWF variants to refine the global genetic prevalence of von Willebrand disease (VWD).
By filtering 10,397 VWF variants down to this high‑confidence pathogenic set and applying Hardy–Weinberg models, the authors report a strikingly high global prevalence:
- approximately 11 per 1,000 for type 1 (≈1.1% of the population)
- 1.3–1.7 per 1,000 for dominant type 2 variants (2A, 2B, 2M)
- Tens per million for recessive forms (≈34 per million for 2N and ≈1–2 per million for type 3)
- Altogether, this translates into tens of millions of affected individuals worldwide.
The study further maps pathogenic variant clustering across functional VWF domains and highlights ancestry‑specific distributions of key alleles, underscoring both shared VWF biology and population‑specific risk patterns.
For clinical and research practice, these data provide a valuable reference for variant interpretation, support more realistic registry and screening strategies, and reinforce that VWD—particularly mild and qualitative forms—remains substantially underdiagnosed and undertreated.
Congratulations to Omid Seidizadeh, Andrea Cairo, Camilla Oriani and Flora Peyvandi.”
Title: Updated global prevalence and ethnic diversity of von Willebrand disease based on population genetics analysis
Authors: Omid Seidizadeh, Andrea Cairo, Camilla Oriani, Flora Peyvandi
Stay updated on all scientific advances with Hemostasis Today.
-
Nov 10, 2026, 16:28Can the VWF to ADAMTS-13 Ratio Predict Mortality in Sepsis-Induced Coagulopathy? – RPTH Journal
-
Nov 10, 2026, 16:28Ruth Willems: PhD Defence at Maastricht University on Thrombosis and Bleeding in HPB Disease
-
Nov 10, 2026, 16:09Edward Lee Carter: Factor XIa Inhibition Enters Clinical Practice
-
Nov 10, 2026, 16:08Edward C.C. Wong: Deriving Ferritin Cutoffs for Iron Deficiency Using RBC Parameters
-
Nov 10, 2026, 16:07Milad Abdalla: Decoding Hemoglobin Electrophoresis – A Practical Diagnostic Reference
-
Nov 10, 2026, 15:13Wolfgang Miesbach: Nonviral Gene Therapy for Haemophilia A Using Lipid Nanoparticles
-
Nov 10, 2026, 15:06Dahra Teles: First Speaking Experience at HEMO 2026 on First-Line Multiple Myeloma Treatment
-
Nov 10, 2026, 14:55Yazan Abou-Ismail: First FDA-Approved Factor XIa Inhibitor for Stroke Prevention
-
Nov 10, 2026, 14:49Ifeanyichukwu Ifechidere: The Role of Coagulation in Anaesthesia and Surgery