Priya Prasad: In Massive Hemorrhage, Fibrinogen Is Often the First Clotting Factor to Fall
Priya Prasad, Senior Specialist at Caritas Hospital, shared a post on LinkedIn:
“When a patient is bleeding out, one link is too often forgotten.
Platelets and fibrinogen work together.
The part that gets missed:
In massive haemorrhage, fibrinogen is often the first clotting factor to fall — sometimes before the platelet count even drops.
Focus only on platelets or the INR, and you can miss the very thing holding the clot together. Activated platelets can’t form a stable plug on their own!
Fibrinogen is the bridge that binds them, linking platelet to platelet through their GPIIb/IIIa receptors. Thrombin then converts that fibrinogen into fibrin – the mesh that locks the whole clot in place.
So don’t stop at platelets!
Ask for platelets and cryoprecipitate. Let that bond do what it’s designed to do — form a clot.”
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