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Lucio D’Anna: Can Inflammatory Biomarkers Identify Residual Risk in Atrial Fibrillation?
Lucio D'Anna/X
Nov 2, 2026, 21:55

Lucio D’Anna: Can Inflammatory Biomarkers Identify Residual Risk in Atrial Fibrillation?

Lucio D’Anna, Consultant in Stroke Medicine at Imperial College NHS Trust, Honorary Senior Lecturer at Imperial College London, shared a post on X about a recent article he and his colleagues co-authored, published in Stroke, adding:

“Why do patients with atrial fibrillation continue to experience ischemic events despite anticoagulation?

Anticoagulation reduces thromboembolic risk, but residual risk remains.

Could inflammation help identify patients at higher risk?

Our new ASPERA-R study in Stroke.

In 671 patients across 14 centres, high inflammatory burden was associated with:

  • 53% higher risk of ischemic events
  • 70% higher mortality
  • 2.2 times the odds of hemorrhagic transformation
  • 2.9 times the hazard of major bleeding

Routine biomarkers may help identify residual risk.”

Title: Impact of Inflammatory Burden on Outcomes After Breakthrough Ischemic Stroke: Insights From the ASPERA-R Study

Authors: Lucio D’Anna, Gabriele Prandin, Federico De Santis, Francesca Gabriele, Raffaele Ornello, Angelo Cascio Rizzo, Maria Sessa, Ghil Schwarz, Rachele Tortorella, Leonardo Pantoni, Francesco Mele, Giuseppe Scopelliti, Ilaria Cova, Barbara Casolla, Monica Gulla, Souleymane-M-Bara Diallo, Marjolaine Baude, Laura González, Ricardo Rigual, Blanca Fuentes, Pietro Caliandro, Aurelia Zauli, Giuseppe Reale, Ahmed Abdelalim, Sandra Ahmed, Samah Ali Ismail, Liqun Zhang, Tara Latimer, Muhammad Elboghday, Federica Ferrari, Federico Mazzacane, Ana Catarina Fonseca, Bernardo Antunes, Maria Grazia Piscaglia, Giorgia Balducci, Ludovica Maria Miserocchi, Marialuisa Zedde, Ahmed Elsaid Elsayed, Gurav Desai, Muhammad Jaffar, Soma Banerjee, Alexandros Polymeris, Simona Sacco, Matteo Foschi

Lucio D’Anna

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AF Ahmed Abdelalim Ahmed Elsaid Elsayed Alexandros Polymeris Ana Catarina Fonseca Angelo Cascio Rizzo ASPERA-R Atrial Fibrillation Aurelia Zauli Barbara Casolla Bernardo Antunes Blanca Fuentes Blood Federica Ferrari Federico De Santis Federico Mazzacane Francesca Gabriele Francesco Mele Gabriele Prandin Ghil Schwarz Giorgia Balducci Giuseppe Reale Giuseppe Scopelliti Gurav Desai Health Hematology Hemostasis Hemostasis News Hemostasis Today Ilaria Cova Laura González Leonardo Pantoni Liqun Zhang Lucio D’Anna Ludovica Maria Miserocchi Maria Grazia Piscaglia Maria Sessa Marialuisa Zedde Marjolaine Baude Matteo Foschi Medicine Monica Gulla Muhammad Elboghday Muhammad Jaffar Pietro Caliandro Rachele Tortorella Raffaele Ornello Ricardo Rigual Samah Ali Ismail Sandra Ahmed Simona Sacco Soma Banerjee Souleymane-M.-Bara Diallo stroke Tara Latimer
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