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Alfadil Haroon: Bleeding Outcomes in Congenital Versus Acquired FXIII Deficiency
Alfadil Haroon/Photo: researchgate.net
Jun 16, 2026, 14:23

Alfadil Haroon: Bleeding Outcomes in Congenital Versus Acquired FXIII Deficiency

Alfadil Haroon, Assistant Consultant of Hematology at King Faisal Specialist Hospital and Research Centre, Assistant Professor at Alfaisal University, shared a post on LinkedIn about a recent article he and his colleagues co-authored, published in HemaSphere, adding:

“Factor XIII Deficiency: Congenital versus Acquired

Study overview

  • 25 patients (52 percent congenital, 48 percent acquired)
  • Median age: 35 years

Congenital FXIII deficiency:

  • Diagnosed early (younger patients)
  • Very low FXIII levels
  • Managed with long-term prophylaxis
  • Lower bleeding risk (46 percent)

 Acquired FXIII deficiency:

  • Occurs later (median approximately 60 years)
  • Strongly linked to malignancy (92 percent)
  • Higher FXIII levels than congenital
  • Severe bleeding in 92 percent

 Bleeding Patterns:

  • Acquired FXIIID – more severe bleeding
  • GI bleeding: 41.6 percent
  • Muscle/joint: 33.3 percent

Congenital FXIIID

  • Mucosal bleeding only in this group
  • CNS bleeding similar in both groups (approximately 15–16 percent)

Key Biomarker Insight

  • FXIII level predicts bleeding only moderately
  • AUC equals 0.70
  • Best cutoff: 0.13 IU/mL

Management Highlights

Congenital: Long-term FXIII replacement (92 percent)

Acquired: Treat underlying disease (especially malignancy), FXIII plus antifibrinolytics for bleeding

Take-Home Messages

  • Congenital is not Acquired – completely different diseases
  • Acquired FXIIID equals high-risk bleeding disorder
  • FXIII level alone is not enough for risk stratification

Clinical Pearl

Patients with acquired FXIII deficiency bleed more despite higher factor levels – highlighting the importance of etiology over numbers.”

Title: Distinct Clinical Profiles and Bleeding Severity in Congenital and Acquired Factor XIII Deficiency: A Single-Center Experience

Authors: Alfadil Haroon, Tusneem Alhassan, Hazzaa Alzahrani

Alfadil Haroon: Bleeding Outcomes in Congenital Versus Acquired FXIII Deficiency

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Alfadil Haroon Factor XIII deficiency Hazzaa Alzahrani Health Hematology Hemostasis Hemostasis News Hemostasis Today Medicine Tusneem Alhassan
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