Bruno Pougault: Heparin Monitoring Remains One of the Most Challenging Areas in Laboratory Hemostasis
Bruno Pougault, Global Marketing Hemostasis Product Manager at HORIBA, shared on LinkedIn:
“Heparin monitoring remains one of the most challenging areas in laboratory hemostasis.
While chromogenic Anti-Xa assays are increasingly the gold standard over aPTT due to their superior specificity and reduced interference, a critical question often goes overlooked in clinical practice.
Are we truly capturing the patient’s physiological heparin status, or are we just seeing the effect of our reagent selection?
From the impact of Dextran Sulfate (DXS) causing artifactual dissociation of heparin complexes, to the critical nature of PF4-mediated neutralization during pre-analytical phases, the way we measure is as vital as the numerical result itself.
With the ISTH 2026 Congress in Paris just a week away, heparin monitoring is taking center stage. Several sessions in the upcoming program are dedicated to this exact topic, highlighting how analytical variables directly influence clinical decision-making and patient safety in high-stakes environments like cardiac surgery and critical care.
In the carousel below, we break down:
- Why assay choice matters (The ‘DXS’ variable).
- How to master pre-analytical variables to avoid underestimation.
- Current 2024–2026 best practices from ISTH, BSH, and SFH guidelines.
Reliable monitoring requires more than just measuring activity—it requires a deep understanding of how that activity is being measured.
Are you attending ISTH 2026? Let’s connect and discuss the future of hemostasis monitoring.”
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