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ADAMTS13 and Vascular Cognitive Impairment in the Heart–Brain Connection Study – JTH
First author of the article - Amos Pomp/LinkedIn
Jul 6, 2026, 11:06

ADAMTS13 and Vascular Cognitive Impairment in the Heart–Brain Connection Study – JTH

Journal of Thrombosis and Haemostasis (JTH) shared on LinkedIn about a recent article by Amos Pomp et al, adding:

”ADAMTS13 and von Willebrand Factor in relation to vascular cognitive impairment and cerebral small vessel disease: the heart-brain connection study

In 267 participants from the Heart-Brain Connection study, lower ADAMTS13 activity was independently associated with vascular cognitive impairment (OR 1.46 per SD decrease), whereas elevated von Willebrand factor was not.

Both lower ADAMTS13 and higher VWF correlated with markers of cerebral small vessel disease, including white matter hyperintensities and lacunes.’

Title: ADAMTS13 and von Willebrand Factor in relation to vascular cognitive impairment and cerebral small vessel disease: the heart-brain connection study

Authors: Amos Pomp, Mathijs Rosbergen, Moniek de Maat, Paul S. de Vries, Arfan Ikram, Mat Daemen, Imo Hoefer, Wiro Niessen, Jeroen de Bresser, Esther Bron, Charlotte Teunissen, Geert Jan Biessels, Robert van Oostenbrugge, Frank Wolters

ADAMTS13 and Vascular Cognitive Impairment in the Heart–Brain Connection Study - JTH

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ADAMTS13 Amos Pomp Arfan Ikram bleeding disorders Charlotte Teunissen Esther Bron Frank Wolters Geert Jan Biessels Health Heart-Brain Connection Hematology Hemostasis Hemostasis News Hemostasis Today Imo Hoefer Jeroen de Bresser JTH Mat Daemen Mathijs Rosbergen Medicine Moniek de Maat Paul S de Vries Robert van Oostenbrugge VWD VWF Wiro Niessen
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