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Deborah Siega: What Predicts Bleeding in Anticoagulated Patients
Deborah Siega/LinkedIn
Aug 6, 2026, 23:22

Deborah Siega: What Predicts Bleeding in Anticoagulated Patients

Deborah Siega, Associate Professor, Department of Medicine at University of Ottawa, shared a post on LinkedIn about a recent article she and her colleagues co-authored, published in Circulation, adding:

“Newly published in Circulation

Bleeding remains the major complication of oral anticoagulation, but are we focusing on the right bleeding outcome?

In this COMBINE-AF individual patient meta-analysis of 73,737 patients, we found:

  • 1 in 4 patients experienced clinically relevant extracranial bleeding over ~2 years
  • Clinically relevant non-major bleeding accounted for the majority of bleeding events
  • Low hemoglobin, impaired kidney function, prior stroke, cancer and Asian ancestry were among the strongest predictors
  • Known risk factors explained only ~2/3 of bleeding risk, far less than for stroke or MI, underscoring the need for novel predictors

The next step: understanding what these bleeds actually mean for patients!”

Title: Incidence and Predictors of Extracranial Bleeding on Oral Anticoagulants for Stroke Prevention in Patients With Atrial Fibrillation: A COMBINE-AF Analysis

Authors: Deborah M. Siegal, Marc Carrier, M. Cecilia Bahit, Jackie Bosch, Alexander P. Benz, Brian Bergmark, Robert P. Giugliano, Christopher B. Granger, Victorien Monguillon, Martin O’Donnell, Jonas Oldgren, Manesh R. Patel, Rohin K. Reddy, Lars Wallentin, Qilong Yi, Andre Zimerman, John Eikelboom

Deborah Siega: What Predicts Bleeding in Anticoagulated Patients

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Alexander P. Benz Andre Zimerman Brian Bergmark Christopher B. Granger COMBINE AF Deborah M. Siegal Health Hematology Hemostasis Hemostasis News Hemostasis Today Jackie Bosch John Eikelboom Jonas Oldgren Lars Wallentin M. Cecilia Bahit Manesh   R. Patel Marc Carrier Martin O'Donnell Medicine Qilong Yi Robert P. Giugliano Rohin K. Reddy Victorien Monguillon
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