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Understanding Antiphospholipid Syndrome (APS): Diagnosis and Clinical Clues Every Clinician Should Know-by APS Foundation of America
Clinical Feautures APS/X
Jun 12, 2025, 09:14

Understanding Antiphospholipid Syndrome (APS): Diagnosis and Clinical Clues Every Clinician Should Know-by APS Foundation of America

The APS Foundation of America has pinned a critical update on their X page, shedding light on the diagnostic criteria and clinical features of Antiphospholipid Syndrome (APS)—a serious autoimmune condition that significantly increases the risk of blood clots, pregnancy complications, and organ damage.

Diagnosis of APS requires both clinical manifestations and positive laboratory findings. The most commonly used tests include:
  • Anticardiolipin antibodies (IgG, IgM, IgA)
  • Lupus anticoagulant testing (e.g., dRVVT, aPTT, mixing studies)
  • Anti-β2 glycoprotein I antibodies (IgG, IgM, IgA)
These tests help differentiate APS from other causes of coagulopathy and are essential for accurate classification and management.
 Clinical features may include:
  • Recurrent venous or arterial thrombosis
  • Recurrent miscarriages or severe pregnancy complications (e.g., pre-eclampsia)
  • Thrombocytopenia
  • Stroke or transient ischemic attacks
  • Livedo reticularis, skin ulcers, and — in severe cases — Catastrophic APS
APS is a multisystemic disorder that requires high clinical suspicion, especially in young patients with unexplained thrombotic events or adverse pregnancy outcomes.

APS Diagnosed

See full details and expert perspectives now on Hemostasis Today.

American Society of Hematology Anticardiolipin Antibodies Antiphospholipid Syndrome APS Awareness APS Diagnosis APSFA Autoimmune Coagulopathy Catastrophic APS Hematology Hemostasis Today International Society on Thrombosis and Haemostasis (ISTH) Lupus Anticoagulant Pregnancy Loss Th APS Foundation of America thrombosis β2 Glycoprotein I
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