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Patrick Badertscher: PVI With vs Without Posterior Wall Isolation in Persistent AF
Patrick Badertscher, Laurent Roten/LinkedIn
Sep 14, 2026, 06:36

Patrick Badertscher: PVI With vs Without Posterior Wall Isolation in Persistent AF

Patrick Badertscher, Privat-Docent (PD) in Cardiology at University of Basel, shared a post on LinkedIn about a recent article by Laurent Roten et al., published in JAMA, adding:

“Exited to share PIFPAF-PFA.

Today, the PIFPAF-PFA randomized trial was presented as a Late-Breaking Clinical Trial at ESC Congress 2026 and simultaneously published in JAMA

We asked: In persistent AF, should posterior wall isolation be added to PVI when using pulsed-field ablation?

PVI and PWI did not significantly improve freedom from atrial tachyarrhythmia compared with PVI alone.

However, continuous rhythm monitoring showed lower arrhythmia burden and fewer longer-lasting episodes with PWI.

Our findings challenge us to look beyond the traditional greater-than-30-second recurrence endpoint when assessing AF ablation outcomes.

Proud to have been part of this investigator-initiated trial and grateful to all patients, investigators, study teams, and participating centers who made it possible.”

Title: Pulmonary Vein Isolation Using Pulsed Field Ablation With vs Without Posterior Wall Isolation in Patients With Symptomatic Persistent Atrial Fibrillation

Authors: Laurent Roten, Jens Maurhofer, Philipp Krisai, Alexander Breitenstein, Pascal Koepfli, Ardan M. Saguner, Florian Franzeck, Patrizio Pascale, Thomas Kueffer, Sven Knecht, Corinne Jufer, Valon Spahiu, Nicolas Schaerli, Claudia Herrera Siklody, Gregor Thalmann, Nikola Kozhuharov, Boldizsar Kovacs, Felix Mahfoud, Dik Heg, Tiago V. Pereira, Helge Servatius, Hildegard Tanner, Michael Kühne, Christian Sticherling, Tobias Reichlin, Peter Jüni, Patrick Badertscher
Patrick Badertscher: PVI With vs Without Posterior Wall Isolation in Persistent AF

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AF ablation Alexander Breitenstein Ardan M. Saguner Atrial Fibrillation Boldizsar Kovacs cardiac electrophysiology Cardiology Christian Sticherling Claudia Herrera Siklody Clinical Trial Corinne Jufer Dik Heg Electrophysiology ESC Congress 2026 Felix Mahfoud Florian Franzeck Gregor Thalmann Helge Servatius Hemostasis News Hemostasis Today Hildegard Tanner JAMA Jens Maurhofer Late-Breaking Clinical Trial Laurent Roten Michael Kühne Nicolas Schaerli Nikola Kozhuharov Pascal Koepfli Patrick Badertscher Patrizio Pascale persistent atrial fibrillation Peter Jüni PFA Philipp Krisai PIFPAF-PFA posterior wall isolation pulmonary vein isolation Pulsed Field Ablation PVI Sven Knecht Thomas Kueffer Tiago V. Pereira Tobias Reichlin Valon Spahiu
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