Akhil Antony Konkoth: Targeting Galectin-9 to Reduce Thrombus Formation Without Impairing Haemostasis
Akhil Antony Konkoth, Research Fellow (BHF) in Cardiovascular Sciences at University of Birmingham, shared a post on LinkedIn:
“Delighted to share that our preprint, ‘Galectin-9 drives thrombo-inflammatory circuits initiating venous thrombosis,’ is now available on bioRxiv!
In this study, we show that Galectin-9 contributes to venous thrombosis by promoting platelet activation, neutrophil recruitment, and NET formation, while genetic deletion or neutralisation of Galectin-9 reduces thrombus formation without impairing haemostasis.
This work brings together human DVT samples, platelet, neutrophil, and endothelial biology, whole-blood flow assays, and in vivo thrombosis models to identify Galectin-9 as a potential thrombo-inflammatory target.
I’m incredibly grateful to all of my co-authors and collaborators who contributed to this work, and especially to my mentors Asif Iqbal, Julie Rayes, Alexander Brill, and, Ed Rainger for their guidance, support, and encouragement throughout the project.
I’m also incredibly grateful to Cihan Ay and Daniel Steiner for their collaboration and for providing us with invaluable plasma samples from a cohort of DVT patients, which were an important part of this study.”
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