Caitlin Raymond: How STOP-BABESIOSIS Just Rewrote 40 Years of Practice
Caitlin Raymond, Assistant Professor of Pathology and Transfusion Medicine at University of Wisconsin-Madison, shared a post on LinkedIn:
“We’ve been performing RBC exchange for severe babesiosis since 1980.
Until 2026, the entire controlled evidence base for that practice was 28 patients.
The STOP-BABESIOSIS investigators just changed that.
- 629 patients across 82 sites, 15 years of data
- Sequential target trial emulation to minimize bias
- Nearly 5-fold reduction in death or 30-day readmission with exchange (aOR 0.22, 95% CI 0.09–0.51)
- Consistent across 8 sensitivity analyses
The caveats are real – residual confounding, small death count, readmissions driving most of the composite.
And an RCT is almost certainly never coming.
But for a procedure built on case reports and mechanistic logic for four decades, this is about as close to a definitive answer as we’re going to get.
New post breaks down the evidence – including where the O’Bryan 2021 Yale data fit in – for the overworked fellow trying to make sense of it.”
Other posts featuring Caitlin Raymond on Hemostasis Today.
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Jun 9, 2026, 04:47Akshat Jain: Marstacimab Gets FDA Expension for Children with Hemophilia B
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Jun 9, 2026, 03:30Fayad Al-Haimus: High-Risk Emergencies and Lifelong Learning at CAEP 2026
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Jun 9, 2026, 03:14Rucha Patil: A Collaborative Initiative to Transform Rare Blood Disorder Care in Rajasthan
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Jun 9, 2026, 02:28Andreas Calatzis: Chasing Biologically Inactive Heparin?
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Jun 9, 2026, 02:16Javier Lagos Servellon: Reflections on Completing the University of Bern’s Stroke Medicine Program
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Jun 8, 2026, 17:50From Bleeding to Swelling – A Shared Therapeutic Revolution in Rare Diseases – RPTH Journal
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Jun 8, 2026, 17:36Sophia Delicou: Decoding Acute Pain Transfusion Reactions in Thalassemia
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Jun 8, 2026, 16:21Ifeanyichukwu Ifechidere: Reflections on the UK NEQAS Coagulation and Haemostasis Conference
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Jun 8, 2026, 16:00Despina Fotiou: Advancing Recognition Through Global Case Collaboration