Caitlin Raymond: How STOP-BABESIOSIS Just Rewrote 40 Years of Practice
Caitlin Raymond, Assistant Professor of Pathology and Transfusion Medicine at University of Wisconsin-Madison, shared a post on LinkedIn:
“We’ve been performing RBC exchange for severe babesiosis since 1980.
Until 2026, the entire controlled evidence base for that practice was 28 patients.
The STOP-BABESIOSIS investigators just changed that.
- 629 patients across 82 sites, 15 years of data
- Sequential target trial emulation to minimize bias
- Nearly 5-fold reduction in death or 30-day readmission with exchange (aOR 0.22, 95% CI 0.09–0.51)
- Consistent across 8 sensitivity analyses
The caveats are real – residual confounding, small death count, readmissions driving most of the composite.
And an RCT is almost certainly never coming.
But for a procedure built on case reports and mechanistic logic for four decades, this is about as close to a definitive answer as we’re going to get.
New post breaks down the evidence – including where the O’Bryan 2021 Yale data fit in – for the overworked fellow trying to make sense of it.”
Other posts featuring Caitlin Raymond on Hemostasis Today.
-
May 5, 2026, 16:28Nikolay Novitski: A New Era in Cardiovascular Prevention
-
May 5, 2026, 16:23Satyam Arora: Best Abstract Award in Pediatric Apheresis at ASFA 2026 Congress
-
May 5, 2026, 16:17Hannah Omunakwe: Your Sick Child Has a Clot. Did You See That Coming?
-
May 5, 2026, 15:57Venous Thromboembolism Risk in Pregnancy and the Postpartum Period – NBCA
-
May 5, 2026, 15:28Soumen Bhattacharyya: Hyperhomocysteinemia and Thrombosis – What Clinicians Should Know
-
May 5, 2026, 15:06Wolfgang Miesbach: How Should We Approach GI Angiodysplasia in VWD?
-
May 5, 2026, 14:48What Constitutes High Risk for Venous Thromboembolism? – JTH
-
May 5, 2026, 14:41How Real-Time Data, Rehabilitation Registries, and Patient-Reported Outcomes Can Transform Practice – European Stroke Organisation
-
May 5, 2026, 14:41Driving National Change for Bleeding Disorders – WFH