Davide Stradella: Bleeding is an Unpleasant Complication in Endoscopy
Davide Stradella, Consultant Physician (Gastroenterology and Digestive Endoscopy) at Mauriziano Hospital, Turin, shared a post on LinkedIn:
“We need to ensure safety for our patients in every day practice and operative endoscopy.
Bleeding is a unpleasant complication in endoscopy.
We need to know MoA and correct time for withdrawal of principal antiplatelets/anticoagulant
Here’s a Antiplatelets & anticoagulants in endoscopy — practical update for daily practice based on principal guidelines and review.
Balancing bleeding vs thrombotic risk is central to safe endoscopy. Short summary:
• Diagnostic procedures (EGD/colonoscopy without biopsy, ERCP without sphincterotomy): usually do not stop aspirin/warfarin/DOACs — omit morning DOAC dose for low-risk cases.
• High-risk procedures (EMR/ESD, polypectomy >1–2 cm, sphincterotomy): stop P2Y12 inhibitors 5–7 days (clopidogrel/ticagrelor ~5 days, prasugrel ~7), stop warfarin 5 days and ensure INR <1.5, and stop DOACs 48–72 h before (longer if renal impairment). Continue aspirin in most cases. Liaise with cardiology for recent coronary stent/DAPT.
• Urgent bleeding / life-threatening cases: use specific reversal agents where indicated (idarucizumab for dabigatran; andexanet alfa or PCCs for factor-Xa inhibitors) and coordinate with hematology/cardiology.
Short practical tip: document thrombotic risk (stent timing, mechanical valve, recent VTE/AF CHADS-VASc), classify procedure bleed-risk, and have plan for interruption/resumption and for urgent reversal.
1. BSG/ESGE guideline — Endoscopy in patients on antiplatelet or anticoagulant therapy (update 2021; addendum 2024). (full guideline PDF).
2. Veitch AM et al., Gut / Endoscopy (BSG/ESGE summary 2021).
3. ACG/CAG clinical guideline on periprocedural antithrombotic management (2022).
4. International Digestive Endoscopy Network (IDEN) consensus on antithrombotics in endoscopy (2024).
5. Reviews on anticoagulant reversal and peri-endoscopic management (2021–2024).”
Stay informed with Hemostasis Today.
-
Jan 12, 2026, 01:55Frank Weinz on State-of-the-Art Thromboembolism Prophylaxis
-
Jan 12, 2026, 01:45Khurram Nasir on Where The Cholesterol Guidelines Are Headed
-
Jan 12, 2026, 01:35Nirav Dhanesha Shares The Lab’s Latest Publication on Neutrophil CD14 and DVT Link
-
Jan 12, 2026, 01:07Akshat Jain Presents The New Edition of Global Sickle Cell Disease Insight Publication
-
Jan 11, 2026, 21:05Simona Sacco Shares Expert Guidance for Clinicians on Minor Ischemic Stroke
-
Jan 11, 2026, 11:00Benjamin YQ Tan on Impacts of Early Cognitive and Psychological Statuses Post-Stroke
-
Jan 11, 2026, 10:46Salvador Payán Pernía: Leukodepletion Reduces Microplastic Burden in Red Blood Cell Concentrates
-
Jan 11, 2026, 10:36Mariasanta Napolitano on Pregnancy and Delivery Outcomes in Women with Hemophilia
-
Jan 11, 2026, 10:19Quick Explanation of Types of Blood Transfusion from John Amako