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February, 2026
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Mahesan Subramaniam: Supporting Circulation and Managing Cholesterol Protects Heart and Brain
Feb 28, 2026, 12:54

Mahesan Subramaniam: Supporting Circulation and Managing Cholesterol Protects Heart and Brain

Mahesan Subramaniam, Co-Founder of United Health Tourism, shared a post on LinkedIn about a recent article by Zhen Zhou et al. published in Neurology:

Cholesterol is a fat like substance your body needs to build cells and make hormones. But when levels in the blood stay too high for too long it can lead to clogged arteries and reduced blood flow.

New research shows that these changes may also matter for the brain decades before memory issues appear.

When blood vessels become stiff and narrow because of cholesterol buildup, the brain receives less oxygen and nutrients. Over time this can weaken nerve cells and make the brain more vulnerable to the changes that lead to dementia.

In large studies tracking people from middle age into older age, individuals with high cholesterol in their forties and fifties were significantly more likely to develop cognitive impairment later on. That association persisted even after accounting for other health factors.

Experts think that cholesterol related blood vessel damage sets the stage for chronic inflammation and oxidative stress in the brain. These processes interfere with cell communication and waste clearing systems that keep the brain functioning smoothly.

Managing cholesterol through diet, physical activity, and medications when needed may help keep blood vessels healthier for longer.

By supporting good circulation early in life you may not only protect your heart but also support brain resilience as you age.

Title: Association of Year-to-Year Lipid Variability With Risk of Cognitive Decline and Dementia in Community-Dwelling Older Adults

Authors: Zhen Zhou, Chris Moran, Anne M. Murray, Sophia Zoungas, Costan Magnussen, Trevor T.-J. Chong, Raj C. Shah, Kerry M. Sheets, Mark Nelson, Chao Zhu, Andrew M. Tonkin, Stella Talic, Michael E. Ernst, Suzanne G. Orchard, John J. McNeil, Rory Wolfe, Robyn L. Woods, Johannes T. Neumann, Peng Qiu, Joanne Ryan

Read the Full Article on Neurology.

Mahesan Subramaniam: Supporting Circulation and Managing Cholesterol Protects Heart and Brain

 

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