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Matteo Foschi: Cancer Worsens Prognosis after Breakthrough Ischemic Stroke Despite Oral Anticoagulation
Matteo Foschi/LinkedIn
Mar 3, 2026, 17:12

Matteo Foschi: Cancer Worsens Prognosis after Breakthrough Ischemic Stroke Despite Oral Anticoagulation

Matteo Foschi, Neurologist at Azienda USL della Romagna, Affiliated Researcher at the Cochrane MS and Rare Diseases of the CNS Review Group, shared a post on LinkedIn about a recent article he and his colleagues co-authored, adding:

“Excited to share some great news!

I am particularly happy to announce that our paper:

‘Impact of cancer on outcomes following breakthrough ischaemic stroke on oral anticoagulants for atrial fibrillation: insights from the ASPERA-R study’ has been published in the European Stroke Journal.

This publication represents a very special milestone for us — it is the first published paper from the ASPERA-R study, the international collaborative effort investigating breakthrough ischemic stroke despite oral anticoagulation in patients with atrial fibrillation.

And this is only the beginning: several additional ASPERA analyses will be released soon .

Key findings

  • Cancer significantly worsens prognosis after breakthrough ischemic stroke despite oral anticoagulation.
  • Patients with cancer had more than twice the risk of recurrent stroke or TIA within 90 days compared with those without cancer.
  • Cancer was associated with worse functional outcomes, highlighting a more vulnerable clinical phenotype.
  • Bleeding risk was also increased, emphasizing the delicate balance between thrombosis and hemorrhage in this population.
  • Active and haematological cancers emerged as the highest-risk conditions, suggesting the need for personalized secondary prevention strategies.”

Title: Impact of cancer on outcomes following breakthrough ischaemic stroke on oral anticoagulants for atrial fibrillation: insights from the ASPERA-R study

Authors: Matteo Foschi, Federico De Santis, Francesca Gabriele, Lucio D’Anna, Andrea Zini, Matteo Paolucci, Stefano Forlivesi, Ludovica Migliaccio, Maria Maddalena Viola, Angelo Cascio Rizzo, Maria Sessa, Ghil Schwarz, Rachele Tortorella, Soma Banerjee, Gaurav Desai, Muhammad Jaffar, Gabriele Prandin, Leonardo Pantoni, Francesco Mele, Giuseppe Scopelliti, Ilaria Cova, Mariarosaria Valente, Domenico Maisano, Luca Antonelli, Maria Rosaria Bagnato, Giovanni Di Mauro, Francesca Bernocchi, Martina Gaia Di Donna, Barbara Casolla, Myriam Perla Mazloum, Kristina Kacani, Noufel-Anis Djeghlal, Laura González-Martín, Ricardo Rigual, Blanca Fuentes, Carlos Hervás, Paolo Candelaresi, Vincenzo Andreone, Antonio De Mase, Emanuele Spina, Diana Aguiar de Sousa, Mariana Almudi Souza, Alberto Fior, Miguel Serôdio, Pietro Caliandro, Aurelia Zauli, Giuseppe Reale, Ahmed Abdelalim, Sandra Ahmed, Nourhan Mohamed Soliman, Liqun Zhang, Tara Latimer, Muhammad Elboghday, Ahmed Aly Elbassiouny, Tamer Roushdy, Hossam Shokri, Federica Ferrari, Nicola Davide Loizzo, Federico Mazzacane, Maria Guarino, Valentina Barone, Paola Forti, Giuseppe Rinaldi, Marco Vito Rossi, Vincenzo Laterza, Giovanni Frisullo, Pier Andrea Rizzo, Aldobrando Broccolini, Marina Mannino, Valeria Terruso, Marcella Caggiula, Annalisa Rizzo, Ana Catarina Fonseca, Bernardo Antunes, Ana M Barbosa, Hrvoje Budincevic, Petra Crnac, Giovanna Viticchi, Mauro Silvestrini, Lorenzo Barba, Markus Otto, Piergiorgio Lochner, Benjamin Landau, Sandeep Buddha, Roumeisa Khalil, Maria Grazia Piscaglia, Elena Minguzzi, Marialuisa Zedde, Ahmed Nasreldein, Luisa Vinciguerra, Luis Costa, Ahmed Elsaid Elsayed, Mona AlBanna, Laura Tudisco, Maria Giulia Mosconi, Giovanni Merlino, Alexandros Polymeris, Raffaele Ornello, Simona Sacco

Read the Full Article on European Stroke Journal.

Matteo Foschi: Cancer Worsens Prognosis after Breakthrough Ischemic Stroke Despite Oral Anticoagulation

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