Mohamad Al Qassab: How Disruptions in Key Metabolic Pathways Contribute to Vascular Dysfunction and Disease Progression
Mohamad Al Qassab, Research Volunteer at American University, shared a post on LinkedIn, about resent article he and his colleagues co-authored, published in Biochemistry and Biophysics Reports, adding:
“Thrilled to share our latest publication!
Our review article, ‘One-carbon metabolism and cardiovascular disease: Molecular mechanisms, genetic influences, and epigenetic regulation‘, has just been published in Biochemistry and Biophysics Reports.
In this comprehensive review, we explore the complex relationship between one-carbon metabolism (OCM) and cardiovascular disease (CVD), highlighting how disruptions in key metabolic pathways contribute to vascular dysfunction and disease progression.
We examine the central role of hyperhomocysteinemia and its impact on endothelial function, oxidative stress, inflammation, and atherogenesis.
We further integrate genetic and epigenetic perspectives, discussing how polymorphisms, particularly in enzymes such as MTHFR, and epigenetic modifications including DNA methylation, histone regulation, and non-coding RNAs shape cardiovascular risk and disease heterogeneity.
Importantly, we emphasize how nutritional factors, especially B vitamins and folate, interact with these pathways to influence both disease development and therapeutic response.
Beyond mechanistic insights, the review critically evaluates current evidence on homocysteine-lowering strategies and B-vitamin supplementation, addressing the gap between strong biological rationale and mixed clinical outcomes.
We also highlight emerging directions in personalized medicine, where metabolic, genetic, and epigenetic profiling may guide more targeted cardiovascular prevention and treatment.
It was a pleasure collaborating with an outstanding multidisciplinary team, Raghid Kadbey, Yara El Ratel, Maysaa Zahr, and I am especially grateful to Frederic Harb, MSc, MBA, PhD for his mentorship and guidance throughout this work.”
Title: One-carbon metabolism and cardiovascular disease: Molecular mechanisms, genetic influences, and epigenetic regulation
Authors: Mohamad Al Qassab, Ayman Bou Ghanem, Yaman Hussayni, Raghid Kadbey, Yara Ratel, Shereen Yehya, Maysaa Zahr, Hilda E. Ghadieh, Ziad Abi Khattar, Sami Azar, Amjad Kanaan, Frederic Harb
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