Wolfgang Miesbach: Efficacy, Safety and Thrombosis Signals in Haemophilia A/B with Inhibitors
Wolfgang Miesbach, Professor of Medicine at Frankfurt University Hospital, shared a post on LinkedIn:
”Efficacy, safety and thrombosis signals in haemophilia A/B with inhibitors. This was the last presentation of the 19th EAHAD Congress 2026 (Dublin) by Johnny Mahlangu et al.
In BASIS, once‑weekly SC marstacimab reduced treated ABR from 19.8 to 1.4, lowered annual bypassing agent use, and led to resolution of baseline target joints in 97.1% of patients, with no new target joints over 12 months.
In the BASIS OLE, low ABRs (≈1.2 per year over years 1–3) were maintained, without treatment‑related discontinuations. One participant with inhibitors, multiple comorbidities and intensive perioperative rFVIIa exposure developed cerebral infarction followed by intracerebral haemorrhage more than three years after starting marstacimab and died shortly after discharge.
These events occurred while marstacimab had been administered up to 5 days before surgery and rFVIIa was being used frequently around urological surgery.
To date, two thrombotic events (one venous, one arterial) have been reported in the OLE. Overall, the investigators conclude that SC marstacimab QW reduces bleeding, bypassing agent use and target joints in inhibitor patients with the OLE underlining the need for careful thrombotic risk assessment and perioperative planning when combining non‑factor prophylaxis with bypassing agents.”
Find more posts featuring Wolfgang Miesbach on Hemostasis Today.
-
Oct 9, 2026, 11:51Sumaiya Dickens: Marginal Zone B Cells in Transfusion Medicine and Hemophilia A Research
-
Oct 9, 2026, 11:44Ayyappan V Nair: PRP and Rehabilitation – Can It Help Athletes with Partial Rotator Cuff Tears?
-
Oct 9, 2026, 11:29Jigesha Dholakia: Supporting the Hemophilia Community Through the Unite Walk
-
Oct 9, 2026, 11:06Nobles Green: How siRNA Therapy Helps the Body Form Stronger Clots
-
Oct 9, 2026, 10:53Switching From Emicizumab to Denecimig in Hemophilia A – Rare Disease Advisor
-
Oct 9, 2026, 10:40What New U.S. Data Reveal About GT – Glanzmann’s Research Foundation
-
Oct 9, 2026, 10:32Anjali Pandey: The Morphologic Clues to MDS With del(5q)
-
Oct 9, 2026, 10:13Reza Shojaei: 5 Leadership Responsibilities for a Sustainable Plasma Ecosystem
-
Oct 9, 2026, 08:38Johannes Gratz: Perioperative Care in Factor VII Deficiency – Treating the Patient, Not the Number