Wolfgang Miesbach: Discussing Immunological Challenges in Hemophilia at GTH 2026
Wolfgang Miesbach, Professor of Medicine at Frankfurt University Hospital, shared a post on LinkedIn:
“A standout session at GTH was ‘The immunogenicity of therapeutic proteins in hemostasis – an overview’ by Sebastien Lacroix-Desmazes.
The talk clearly highlighted the immunological challenges in haemophilia — from classical FVIII inhibitors to gene therapy and anti-drug antibodies (ADAs) against newer engineered therapies.
One especially interesting point: FVIII-mimetic bispecific antibodies do not seem to share the same immunogenic profile
- Emicizumab։ ADA signal reported
- NXT007։ ADA signal also observed in early studies
- Mim8։ no ADA signal in the study presented
A likely reason is molecular design:
- Emicizumab is a humanized and highly engineered bispecific antibody; such optimization can improve function, but may also introduce non-self sequences or neoepitopes.
- NXT007, as a further optimized derivative, may retain or add immunogenic determinants.
- Mim8, with a more fully human design strategy, may reduce immune recognition
Take-home message:
Shared mechanism does not equal shared immunogenicity. Even when therapies target the same pathway, immune responses can differ because of humanization strategy, sequence design, and epitope architecture.”
Find more posts featuring Wolfgang Miesbach on Hemostasis Today.
-
Sep 21, 2026, 04:06Allison Lewin: How Gender Shapes the Way We Receive Medical Care
-
Sep 21, 2026, 03:49Jessica Lee: Walking Together for a Stronger Bleeding Disorders Community
-
Sep 21, 2026, 03:36Syed Asif Ali Shah: From Pakistan to Australia – A Clinical Haematology Milestone
-
Sep 21, 2026, 03:22Katie Baca-Motes: Estradiol Fluctuations May Help Explain Menstrual Migraine
-
Sep 21, 2026, 03:00Family History Can Reveal Hidden Risk of Aortic Dissection – The Marfan Foundation
-
Sep 21, 2026, 02:47Transitioning from Paediatric to Adult Haemophilia Care – Haemophilia Foundation Australia
-
Sep 21, 2026, 02:29Diana Castro Paupério: A New Era for Patient Blood Management
-
Sep 21, 2026, 00:29Iheanyichukwu Ike: Childhood Anaemia in Nigeria Through an Analysis of the 2018 NDHS
-
Sep 21, 2026, 00:27Nicole De Vita: The Global Burden of Iron Deficiency and Anemia in Women at SABM