On the Chessboard of Blood Donation: Abdul Mannan Reviews a Complex Case
Abdul Mannan, Consultant Haematologist at Betsi Cadwaladr University Health Board, shared on LinkedIn:
”When the blood bank calls with ‘this one is complicated‘…
97 years old. Hb 65 g/L. Pale, tachycardic, systolic murmur. But the real challenge?
Not the anaemia. Not the age. Not the frailty.
- Auto anti-I, anti-HI, historic anti-e
- DAT: strongly C3d positive, IgG negative
- Cold agglutinin haemolysis + hypoalbuminemia
Suddenly, transfusion becomes less about giving blood and more about playing chess with physiology and immunology at the same time.
• Warmed, carefully selected, antigen-negative units
• AB RhD-positive, e-negative blood as the safest bet
• Meticulous warming protocols
• Slower rates + eagle-eyed monitoring for TACO
In geriatric transfusion medicine, sometimes the “easy” decision—just give blood—becomes a masterclass in precision, restraint, and physiology.
A reminder: transfusion is never just about red cells. It’s about the patient in front of you.”
Read the full case review here.
Review article: Comprehensive Case Review: Complex Cold Antibody Transfusion Challenge
Authors: Abdul Mannan
Stay informed with Hemostasis Today.
-
Jan 15, 2026, 15:09Louise St Germain Bannon: ISTH Education is Off to An Exciting Start in 2026
-
Jan 15, 2026, 13:12Michele Romoli: What is The Optimal Treatment Strategy After Stroke While on DOAC?
-
Jan 15, 2026, 12:18Isabelle Mahé on Reduced Dose Apixaban and Cancer-Associated VTE
-
Jan 15, 2026, 04:52Lucien Blondel on Resolve Stroke: To Be Used In the SCULPT Trial
-
Jan 15, 2026, 04:40Mitchell Elkind: Mental Disorders, Brain Health, and Acute Coronary Syndrome
-
Jan 15, 2026, 04:31Laura Dormer on Comparing Stroke Care in Medicare Advantage Versus Fee-for-Service
-
Jan 14, 2026, 21:15Cihan Ay Congratulates Cornelia Englisch on Successful Completion of Her PHD
-
Jan 14, 2026, 20:53Ana Sachetto on Reporting Negative Results
-
Jan 14, 2026, 16:22Leo Nicolai and Rainer Kaiser Link Procoagulant Platelets and Thromboinflammation in CVD