Chokri Ben Lamine: Approach to Intra-Operative Bleeding in G6P Deficiency – Key Causes and Management
Chokri Ben Lamine, Adult Hematology and Stem Cell Transplantation Assistant Consultant at Oncology Center of Excellence at King Faisal Specialist Hospital and Research Center, shared a post on X:
“G6PD Deficiency and Intra-Operative Bleeding
Differential Diagnosis (DDx)
Not always due to G6PD deficiency itself! Think:
•Oxidative drug exposure (e.g., sulfa, quinolones, methylene blue) → acute hemolysis → anemia → bleeding risk
• Sepsis / stress → hemolysis
•Coagulopathy unrelated to G6PD (DIC, liver dysfunction, massive transfusion effect)
•Surgical/technical bleeding cause
•Platelet dysfunction (drugs, uremia)
•Vitamin K deficiency / anticoagulant exposure
Approach
•Stabilize – secure hemodynamics, transfuse PRBC/FFP/platelets as indicated
•Stop oxidative triggers – avoid sulfa, dapsone, quinolones, methylene blue
•Investigate – CBC, retics, LDH, haptoglobin, bilirubin, smear (Heinz bodies, bite cells )
•Correct coagulopathy – INR/PTT, fibrinogen → give FFP, cryo as needed
•Rule out surgical cause – surgical hemostasis review
•Support – hydration, urine alkalinization if hemolysis with hemoglobinuria
•Consult hematology – intra-op support plan, transfusion thresholds
Key Pearl:
Bleeding in G6PD deficiency intra-op is usually secondary to oxidant-induced hemolysis + anemia or unrelated acquired coagulopathy, not a primary platelet/clotting defect.”
More posts featured in Hemostasis Today.
-
Oct 28, 2025, 14:27Maha Othman on 10-Year Anniversary of the CanVECTOR Research Network!
-
Oct 28, 2025, 14:00Claudio Laudani on PCSK9 Association with Increased Platelet Reactivity: A Pooled Analysis
-
Oct 28, 2025, 13:31Laurent Bertoletti Invites You to The INNOVTE and GITA Joined Meeting on Hormones and Thrombosis
-
Oct 28, 2025, 12:28Courtney Lawrence: Honored to Team Up with BET on Blood at AABB 2025
-
Oct 27, 2025, 19:45Benedikt Lorenz on Liver Failure and Coagulation – Myths, Traps, and Bad Habits
-
Oct 28, 2025, 13:09Gregory Piazza on CORONA-VTE Network Analysis
-
Oct 27, 2025, 18:42Khaled Musallam Shares BEYOND Trial Phase 2 Insights on Luspatercept Use in NTD β-Thalassaemia
-
Oct 27, 2025, 13:30Fabrice Cognasse: When Platelets Meet Artificial Intelligence!
-
Oct 27, 2025, 13:00Hossam El Benawi Shares Multi Site LVT Study from Mayo Clinic
-
Oct 27, 2025, 08:01Acquired Hemophilia A (AHA) is Rare and Often Missed - RPTH Journal
-
Oct 25, 2025, 07:42Adithya Hande: India’s Silent Killer and a Scientific Breakthrough
-
Oct 23, 2025, 09:57Arun V. J: Artificial Blood Is Closer Than You Think
-
Oct 23, 2025, 07:11Sebastien Lobet Presented the ACTIVLIM-Hemo Scale
-
Oct 23, 2025, 07:05Syed Ehsan Shah on Advantages of Werfen HemoCell Automation
-
Oct 22, 2025, 08:25Johanna Nystedt: Not Every Day We Can Release a New Blood Product to Meet An Unmet Medical Need!
-
Oct 27, 2025, 15:10David McIntosh Reflects on International Plasma Awareness Week
-
Oct 27, 2025, 13:18Stroke Foundation Welcomes Jacqui McCallum as the New Executive Director
-
Oct 27, 2025, 12:54Guillermo Lahera Forteza on Stroke and Mental Health
-
Oct 27, 2025, 12:37Joshua Ngimbwa Recognised as the Best Male Junior Investigator Awardee at the Tanzania Health Summit
-
Oct 27, 2025, 08:00Rohit Gosain: Revumenib is Now FDA Approved for R/R AML with NPM1 Mutation