Clinical Trials Shaping Medical Practice in the Coming Years, Published in Nature Medicine
Gustavo Monnerat, Deputy Editor at The Lancet, shared on LinkedIn:
“Nature Medicine recently published clinical trials most likely to shape medical practice in the coming years.
Among all of them, these are the ones I personally found most interesting:
-> A next-generation tuberculosis vaccine (M72/AS01E)
The current BCG vaccine works reasonably well in young children, but its protection fades in adolescents and adults. This large phase 3 trial, enrolling 20,000 participants across Africa and Asia, aims to prevent progression to active pulmonary TB.
-> Targeting inflammation in heart disease (IL-6 inhibition with ziltivekimab)
This trial moves cardiovascular prevention beyond cholesterol lowering. By targeting residual inflammatory risk, it reinforces a crucial idea of an inflammation cause.
Two approaches stood out:
– mRNA CAR-T therapies that temporarily reprogram immune cells without permanent DNA editing
– Prime editing of autologous stem cells, correcting genetic defects using the patient’s own cells, with early signals suggesting functional cures in rare diseases”
Find more posts on Hemostasis Today.
-
Jan 12, 2026, 02:21Martin Haluzík on Compariosn of Cardiovascular Outcomes Between Semaglutide and Dulaglutide Therapies
-
Jan 12, 2026, 01:55Frank Weinz on State-of-the-Art Thromboembolism Prophylaxis
-
Jan 12, 2026, 01:45Khurram Nasir on Where The Cholesterol Guidelines Are Headed
-
Jan 12, 2026, 01:35Nirav Dhanesha Shares The Lab’s Latest Publication on Neutrophil CD14 and DVT Link
-
Jan 12, 2026, 01:07Akshat Jain Presents The New Edition of Global Sickle Cell Disease Insight Publication
-
Jan 11, 2026, 21:05Simona Sacco Shares Expert Guidance for Clinicians on Minor Ischemic Stroke
-
Jan 11, 2026, 11:00Benjamin YQ Tan on Impacts of Early Cognitive and Psychological Statuses Post-Stroke
-
Jan 11, 2026, 10:46Salvador Payán Pernía: Leukodepletion Reduces Microplastic Burden in Red Blood Cell Concentrates
-
Jan 11, 2026, 10:36Mariasanta Napolitano on Pregnancy and Delivery Outcomes in Women with Hemophilia