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Clinical Trials Shaping Medical Practice in the Coming Years, Published in Nature Medicine

Gustavo Monnerat/researchgate.net

Dec 22, 2025, 12:43

Clinical Trials Shaping Medical Practice in the Coming Years, Published in Nature Medicine

Gustavo Monnerat, Deputy Editor at The Lancet, shared on LinkedIn:

“Nature Medicine recently published clinical trials most likely to shape medical practice in the coming years.

Among all of them, these are the ones I personally found most interesting:

-> A next-generation tuberculosis vaccine (M72/AS01E)
The current BCG vaccine works reasonably well in young children, but its protection fades in adolescents and adults. This large phase 3 trial, enrolling 20,000 participants across Africa and Asia, aims to prevent progression to active pulmonary TB.

-> Targeting inflammation in heart disease (IL-6 inhibition with ziltivekimab)
This trial moves cardiovascular prevention beyond cholesterol lowering. By targeting residual inflammatory risk, it reinforces a crucial idea of an inflammation cause.

Two approaches stood out:
– mRNA CAR-T therapies that temporarily reprogram immune cells without permanent DNA editing
– Prime editing of autologous stem cells, correcting genetic defects using the patient’s own cells, with early signals suggesting functional cures in rare diseases”

Clinical Trials Shaping Medical Practice in the Coming Years, Published in Nature Medicine