Jim Hoffman։ Targeting NETosis to Improve Perfusion and Reduce Thrombosis in AMI
Jim Hoffman, Former Technical Advisor at Cygnus Technologies, LLC, posted on LinkedIn about a recent article by Robert Chilton et al, published in National Library of Medicine:
”’Overall, understanding the role of NETosis in AMI provides valuable insights into the disease’s pathophysiology and highlights potential therapeutic targets to mitigate the inflammatory and thrombotic components of heart attacks’ Chilton et al 2024
How about helping patients clear NETs/extracellular chromatin from their blood so they can potentially phagocytically remove and catabolize this unwanted chromatin better from their tissues?
This could greatly improve circulatory perfusion, reduce unwanted thrombi formation, and reduce the chances of exacerbated cell death leading to organ dysfunction(s) and failure(s). Poor dietary-related gut dysbiosis, poor insulin and glucose homeostasis are likely directly related and worsened by NETosis dysregulation.”
Title: The web of intrigue: unraveling the role of NETosis within the gut-microbiome-immune-heart axis in acute myocardial infarction and heart failure
Authors: Tai Yasuda, Kate Deans, Aditi Shankar, Robert Chilton
Read the Full Article on National Library of Medicine.
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