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Maxime Dely: What if We Could Leukoreduce Without a Filter?
Maxime Dely/LinkedIn
Oct 25, 2025, 08:31

Maxime Dely: What if We Could Leukoreduce Without a Filter?

Maxime Dely, Sales and Application Specialist in Therapeutic Apheresis and Cell Therapy, shared on LinkedIn:

”What if we could leukoreduce without a filter?

When we talk about leukoreduction, we immediately think of leukocyte filters — disposable devices able to remove over 99% of white blood cells.

But… not everyone has access to them.

In some countries, the cost of this technology remains a major barrier to transfusion safety.

Yet there’s a simple, effective, and affordable alternative: the hard spin.

In many developing countries, the first step in whole blood processing is a soft spin.

This yields two main components:

  • a PRP (platelet-rich plasma),
  • and an RCC (red cell concentrate).

The issue? Around 90% of the residual white blood cells end up in the RCC.

And these cells can cause febrile non-haemolytic transfusion reactions, allergic reactions, and can even impair red cell storage quality.

By performing a hard spin, we create an interface between plasma and red cells — the well-known buffy coat.

That’s where most white cells accumulate.

The result?
A significant reduction in the residual leukocytes within the red cell concentrate — sometimes divided by 2, from 90% to 50% or even lower, depending on the separation and centrifugation settings.

The hard spin isn’t a miracle solution, but it’s a crucial first step toward safer transfusion, especially where resources are limited.

Because sometimes, innovation simply means doing better with what we have.”

Stay updated with Hemostasis Today.

bleeding disorders Health Hematology Hemostasis Hemostasis Today leukocyte filters Leukoreduction Maxime Dely Medicine Plasma Donation PRP RCC thrombosis Transfusion Medicine
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