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Alejandro González Veliz: The Unbroken Connection Between Heart and Brain
Sep 28, 2026, 18:35

Alejandro González Veliz: The Unbroken Connection Between Heart and Brain

Alejandro González Veliz, Interventional Cardiologist at Institute of Cardiology and Cardiovascular Surgery, shared a post on LinkedIn:

“The heart and brain are not separate systems.

They are continuously communicating.

For decades, cardiovascular and neurological diseases have largely been studied and managed within separate clinical silos.

A new perspective published in Circulation highlights why this model may need to change.

Heart failure, atrial fibrillation and myocardial infarction can be associated with cognitive and mental-health consequences. At the same time, stroke and severe psychological stress can affect cardiac function.

The connection involves multiple pathways — autonomic, neurohumoral, microvascular, immune–metabolic and mechanical.

Perhaps even more importantly, many of the upstream risk factors overlap.

Hypertension.

Diabetes.

Smoking.

Obesity.

Hypercholesterolemia.

Depression.

This creates an opportunity: prevention strategies designed around the whole patient rather than a single organ.

The authors propose a future in which cardiovascular trials consider cognitive and mental-health outcomes when appropriate, brain-focused research incorporates cardiovascular endpoints, and clinical care becomes more integrated across cardiology, neurology, psychiatry and rehabilitation.

The message is simple:

The patient does not experience disease in isolated organ systems.

Maybe our research and healthcare systems shouldn’t either.”

Title: Brain and Heart Interconnections: The Path Forward

Authors: Peter P. Liu, Roland von Känel, Mitchell S.V. Elkind

Alejandro González Veliz

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