Deborah Siega: What Predicts Bleeding in Anticoagulated Patients
Deborah Siega, Associate Professor, Department of Medicine at University of Ottawa, shared a post on LinkedIn about a recent article she and her colleagues co-authored, published in Circulation, adding:
“Newly published in Circulation
Bleeding remains the major complication of oral anticoagulation, but are we focusing on the right bleeding outcome?
In this COMBINE-AF individual patient meta-analysis of 73,737 patients, we found:
- 1 in 4 patients experienced clinically relevant extracranial bleeding over ~2 years
- Clinically relevant non-major bleeding accounted for the majority of bleeding events
- Low hemoglobin, impaired kidney function, prior stroke, cancer and Asian ancestry were among the strongest predictors
- Known risk factors explained only ~2/3 of bleeding risk, far less than for stroke or MI, underscoring the need for novel predictors
The next step: understanding what these bleeds actually mean for patients!”
Title: Incidence and Predictors of Extracranial Bleeding on Oral Anticoagulants for Stroke Prevention in Patients With Atrial Fibrillation: A COMBINE-AF Analysis
Authors: Deborah M. Siegal, Marc Carrier, M. Cecilia Bahit, Jackie Bosch, Alexander P. Benz, Brian Bergmark, Robert P. Giugliano, Christopher B. Granger, Victorien Monguillon, Martin O’Donnell, Jonas Oldgren, Manesh R. Patel, Rohin K. Reddy, Lars Wallentin, Qilong Yi, Andre Zimerman, John Eikelboom
Stay updated on all scientific advances with Hemostasis Today.
-
Nov 8, 2026, 19:31Anna Kajaste-Rudnitski: Presenting AAV-Induced p53 Signalling in Human CNS Cells at ESGCT 26
-
Nov 8, 2026, 19:29David McIntosh: Cybersecurity Matters, but Blood Availability Remains the Bigger Challenge
-
Nov 8, 2026, 19:26Wenxue Ma: An Integrative Framework for Macrophage-Mediated Therapeutic Resistance in Cancer
-
Nov 8, 2026, 19:25Yildiz Yigit: Presenting a Polycythemia Vera Case at the MPN Subcommittee Session
-
Nov 8, 2026, 18:56Denis Oduor: Strengthening the Regulation and Delivery of Blood Transfusion and Transplantation Services
-
Nov 8, 2026, 18:28Raghavendra Rao: A Narrative Review on Chronic Venous Disease during Pregnancy
-
Nov 8, 2026, 17:57Dhiren Patel: PLD1-Derived Phospholipids Regulate NAD Kinase and ROS Production in Neutrophils
-
Nov 8, 2026, 17:48Andra T.: What Causes Antiphospholipid Syndrome? – Four Steps, not One Cause
-
Nov 8, 2026, 17:38Nasrin Samadi: Can a Normal Clotting Test Be Misleading?