Erica Sparkenbaugh: PAR1 Modulation with Parmodulins Shows Promise in Sickle Cell Disease
Erica Sparkenbaugh, Assistant Professor at the University of North Carolina at Chapel Hill, shared a post on LinkedIn about a recent article she and Nirupama Ramadas co-authored, adding:
”Nirupama Ramadas and I are pleased to share our latest findings, published in American Society of Hematology journal Blood Journals Portfolio ‘Blood Advances.’
Here we demonstrate that therapeutic modulation of protease activated receptor 1 (PAR1) with parmodulins reduces thromboinflammatory markers and acute chest syndrome in a murine model of sickle cell disease. We are very excited to see where this story goes.
Thank you to Chris Dockendorff and Jacob DeRousse for their fantastic ongoing collaboration. And shout out to my amazing trainees, Joshua Dutton, Kailyn Lowder who performed experiments for this paper as undergrads. They are both in graduate programs now, and I could not be more proud!
Final thanks to Claire K. and Rani Sellers for their veterinary pathology skills.”
Title: Targeting PAR1 Biased Signaling with Parmodulin Reduces Thromboinflammation and Acute Lung Injury in Sickle Cell Disease
Authors: Nirupama Ramadas, Kailyn Lowder, Joshua Dutton, Rebecca Claire Kazen, Rani S Sellers, Jacob T DeRousse, Christopher J Dockendorff, Erica M. Sparkenbaugh
Read the Full Article on American Society of Hematology journal Blood Journals Portfolio ‘Blood Advances.’
Stay updated on all scientific advances with Hemostasis Today.
-
Aug 27, 2026, 13:13Wolfgang Miesbach: Potential Transmission of Haemorrhagic Risk Through Blood Transfusion
-
Aug 27, 2026, 13:09Jignesh Patel: Can Edoxaban and Rivaroxaban Be Prescribed for Breastfeeding Mothers?
-
Aug 27, 2026, 13:09Nouran Abu-Obaid: Anticoagulation for New-Onset Atrial Fibrillation in Critical Illness
-
Aug 27, 2026, 13:04Nabil Chakfe: Carotid Stent Design and Antiplatelet Therapy Influence Thrombosis Risk
-
Aug 27, 2026, 13:01Lukong Hubert Shalanyuy: New Research on Thromboplastin Reagents and PT/INR Reliability
-
Aug 27, 2026, 11:08Sunisha Arora: New EBMT Recommendations Transform the Approach to HSCT in Thalassemia
-
Aug 27, 2026, 10:51Seema Dawood: A Layered Approach to Identifying Thalassemia in the Laboratory
-
Aug 27, 2026, 10:44Ed Smith: Vitalant Expands Hemophilia Center Team With New Career Opportunities
-
Aug 27, 2026, 10:28Narat Srivali: Exploring the Link Between Perioperative Corticosteroids and VTE Risk