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Heghine Khachatryan: Regarding Coagulation Factor Dynamics During Pregnancy in Hemophilia B Carriers
Heghine Khachatryan/LinkedIn
Apr 28, 2026, 14:22

Heghine Khachatryan: Regarding Coagulation Factor Dynamics During Pregnancy in Hemophilia B Carriers

Heghine Khachatryan, Editor-in-Chief of Hemostasis Today, Head of Hemophilia and Thrombosis Center at Yeolyan Hematology and Oncology Center, shared JTH’s post on LinkedIn:

“This study provides an important and thought-provoking challenge to existing paradigms regarding coagulation factor dynamics during pregnancy in hemophilia B carriers.

The observation that antenatal FIX levels may increase—contrary to current guidance—has direct implications for risk stratification, peripartum planning, and therapeutic decision-making.

It underscores the need for individualized longitudinal monitoring rather than reliance on static baseline assumptions.

Moreover, these findings highlight a critical gap in evidence-based recommendations and reinforce the urgency of generating high-quality prospective data to inform updated clinical guidelines.

A valuable contribution toward more precise and personalized hemostatic care in women with inherited bleeding disorders.”

Journal of Thrombosis and Haemostasis (JTH) shared a post on LinkedIn about a recent article by Claire Kelly et al, published in JTH, adding:

“Engineering Bone Marrow in a Dish — A Bloody Business:

Preclinical Opportunities, Translational Use Cases, and a Call for Consensus

This review examines advances in bone marrow organoid development — integrating stem cell engineering, biomaterials, and microphysiologic systems — and proposes consensus benchmarks for an ideal ex vivo human bone marrow niche to overcome translational barriers in drug development and personalized medicine.”

Title: Contrary to current guidance, antenatal factor IX levels increase in female carriers of hemophilia B

Authors: Claire Kelly, Janet Cleary, Catriona Keenan, Isabelle Delachapelle, Leona Connolly, Mary Byrne, Mairead O’Donovan, Niamh M. O’Connell, James S. O’Donnell, Kevin Ryan, Michelle Lavin

Heghine Khachatryan

Other posts featuring Heghine Khachatryan and JTH on Hemostasis Today.

Blood bone marrow Catriona Keenan Claire Kelly FIX Health Heghine Khachatryan Hematology Hemophilia Hemophilia B Hemostasis Hemostasis News Hemostasis Today Isabelle Delachapelle James S. O’Donnell Janet Cleary JTH Kevin Ryan Leona Connolly Mairead O’Donovan Mary Byrne Medicine Michelle Lavin Niamh M. O’Connell Stem Cell
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