Heghine Khachatryan: Regarding Coagulation Factor Dynamics During Pregnancy in Hemophilia B Carriers
Heghine Khachatryan, Editor-in-Chief of Hemostasis Today, Head of Hemophilia and Thrombosis Center at Yeolyan Hematology and Oncology Center, shared JTH’s post on LinkedIn:
“This study provides an important and thought-provoking challenge to existing paradigms regarding coagulation factor dynamics during pregnancy in hemophilia B carriers.
The observation that antenatal FIX levels may increase—contrary to current guidance—has direct implications for risk stratification, peripartum planning, and therapeutic decision-making.
It underscores the need for individualized longitudinal monitoring rather than reliance on static baseline assumptions.
Moreover, these findings highlight a critical gap in evidence-based recommendations and reinforce the urgency of generating high-quality prospective data to inform updated clinical guidelines.
A valuable contribution toward more precise and personalized hemostatic care in women with inherited bleeding disorders.”
Journal of Thrombosis and Haemostasis (JTH) shared a post on LinkedIn about a recent article by Claire Kelly et al, published in JTH, adding:
“Engineering Bone Marrow in a Dish — A Bloody Business:
Preclinical Opportunities, Translational Use Cases, and a Call for Consensus
This review examines advances in bone marrow organoid development — integrating stem cell engineering, biomaterials, and microphysiologic systems — and proposes consensus benchmarks for an ideal ex vivo human bone marrow niche to overcome translational barriers in drug development and personalized medicine.”
Title: Contrary to current guidance, antenatal factor IX levels increase in female carriers of hemophilia B
Authors: Claire Kelly, Janet Cleary, Catriona Keenan, Isabelle Delachapelle, Leona Connolly, Mary Byrne, Mairead O’Donovan, Niamh M. O’Connell, James S. O’Donnell, Kevin Ryan, Michelle Lavin
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