Ivan Tesakov: Unraveling Platelet Dysfunction in ETV6-Related Thrombocytopenia
Ivan Tesakov, Research Fellow of Translational Hematology and Immunology at Tübingen University Hospital, shared a post on LinkedIn about a recent article he and his colleagues co-authored, published in British Journal of Haematology, adding:
“I am pleased to share that our work on ETV6-related thrombocytopenia has just been published in the British Journal of Haematology.
In this study, we identify impaired cytoskeletal organization as a key driver of platelet dysfunction in this rare disorder, leading to defective shape change and altered thrombus formation.
We also observe alterations in platelet–neutrophil cross-talk, further pointing to a broader dysregulation of thrombo-inflammatory processes.
These findings provide a mechanistic explanation for the bleeding phenotype observed in affected patients and may help inform future diagnostic and therapeutic approaches.
This work represents a large, long-term collaborative project.
For me, it is particularly meaningful as my first experience serving as corresponding author and as the culmination of a sustained joint effort.
I am very grateful to all co-authors and colleagues for their contributions.
I am always happy to discuss the work and answer any questions.”
Title: Altered cytoskeletal integrity underlies impaired platelet shape change and defective thrombus formation in ETV6-related thrombocytopenia
Authors: Ivan P. Tesakov, Julia-Jessica D. Korobkin, Daria V. Fedorova, Sofia V. Galkina, Maria M. Golomysova, Sergei I. Obydennyi, Anastasia A. Ignatova, Ekaterina-Iva A. Adamanskaya, Eugenia V. Yushkova, Anna V. Pavlova, Pavel A. Zharkov, Igor I. Kireev, Galina A. Novichkova, Viktor G. Zgoda, Mikhail A. Panteleev, Anastasia N. Sveshnikova
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