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Jim Hoffman on a Critical Question: Should We Track NETosis and Use Blood Purification in Heart Failure?
Jim Hoffman/LinkedIn
Dec 1, 2025, 15:30

Jim Hoffman on a Critical Question: Should We Track NETosis and Use Blood Purification in Heart Failure?

Jim Hoffman, Technical Advisor at Cygnus Technologies, LLC, reposted Shashikant R Iyengar’s post on LinkedIn:

“Do not wait until heart failure is diagnosed. The sooner you convert to a extreme low ket diet, the better. Should we be tracking persistently elevated NETosis induction and poor NET clearance with these studies, especially for patients with more advanced atherogenic vascular disease? You be the judge.

Can blood purification maintenance strategies designed to help metabolically sick patients specifically remove their elevated CRP and/or extracellular chromatin from their circulation santersus.com, substantially delay/reverse their risk of circulatory decline that can lead to organ failure and DIC, by helping boost innate efferocytotic phagocytic clearance when it is obviously underperforming and likely overwhelmed? Both chronically elevated CRP and NETs/nucleosomes are excellent prognostic indicators of multi-disease severity. These markers are also increasingly considered therapeutic targets for improving the treatment of both infectious and non-infectious diseases.

CRP Induces NETosis in Heart Failure Patients with or without Diabetes Sirois et al 2019

Case report: C-reactive protein apheresis in cardiogenic shock: case series from the C-reactive protein apheresis in acute myocardial infarction-registry Torzewski et al 2023

Elevated Levels of Circulating DNA and Chromatin Are Independently Associated with Severe Coronary Atherosclerosis and a Prothrombotic State Wagner et. al. 2014

Neutrophil extracellular traps contributing to atherosclerosis: From pathophysiology to clinical implications. Reviewed by Liu et. al 2023

Neutrophil extracellular traps regulate ischemic stroke brain injury. Campbell et. al. 2022

Evaluating histone H3.1 as a biomarker for acute ischemic stroke: insights into NETs and stroke pathophysiology https://lnkd.in/gXDKWa4f Han et. al. 2024

A Novel Assay for Neutrophil Extracellular Trap Formation Independently Predicts Disseminated Intravascular Coagulation and Mortality in Critically Ill Patients. Toh et al 2019″

Quoting Shashikant R Iyengar’s post:

“A new observational study shows that a ketogenic diet is safe and well-tolerated in patients with obesity and heart failure, leading to significant weight loss and improved metabolic markers. Mortality rates in this observational study were low and hospitalisations dropped markedly compared to the year before the diet. HDL increased while triglycerides and liver enzymes decreased, suggesting broad metabolic benefits.

‘Retrospective Review of the Safety and Effectiveness of a Low-carbohydrate Ketogenic Diet Intervention in Patients With Overweight or Obesity and Heart Failure’ ”

Title: Retrospective Review of the Safety and Effectiveness of a Low-carbohydrate Ketogenic Diet Intervention in Patients With Overweight or Obesity and Heart Failure

Authors: Garrett A. Moseley, William S. Yancy Jr., Eric C. Westman, Senthil Selvaraj, Josephine Harrington

Jim Hoffman on a Critical Question: Should We Track NETosis and Use Blood Purification in Heart Failure?

Read full paper here.

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CRP Eric C. Westman Garrett A. Moseley Health Hematology Hemostasis Hemostasis Today Jim Hoffman Josephine Harrington Medicine NETs Senthil Selvaraj Shashikant R Iyengar William S. Yancy Jr.
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