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Marina Tarunina: Engineered Platelets From Human iPSCs Support Haemostasis Without Thromboembolism
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Jun 6, 2026, 08:25

Marina Tarunina: Engineered Platelets From Human iPSCs Support Haemostasis Without Thromboembolism

Marina Tarunina, Research Director at Plasticell Limited, shared a post on LinkedIn about a recent article she and her colleagues co-authored, published in Thrombosis Research, adding:

“We are pleased to share a new publication from Plasticell’s research team in Thrombosis Research: ‘Human iPSC-Derived Platelets Generated in Alginate Scaffolds Exhibit Functional Haemostasis In Vitro and In Vivo.’

This study is the result of a successful collaboration between Plasticell and Professor Clive Page and Professor Simon Pitchford team at King’s College London.

The research presents a scalable approach for generating mature megakaryocytes and platelets from human induced pluripotent stem cells using Plasticell’s high-throughput CombiCult® platform and alginate-based 3D culture systems.

Importantly, the resulting platelets demonstrated key functional properties, including activation, clot formation and pro-coagulant activity in vitro.

In a murine model, iPSC-derived platelets supported haemostasis without evidence of thrombo-embolism.

This work represents a step toward controlled, cost-effective platelet production for transfusion and regenerative medicine applications.

Congratulations to all authors and collaborators involved.”

Title: Human iPSC-derived platelets generated in alginate scaffolds exhibit functional haemostasis in vitro and in vivo

Authors: Marina Tarunina, Richard Amison, Tatyana Ponomaryov, Lam Lam, Anna Kelis, Shahzad Ali, Cedric Humbert, Abdullah Erikat, Thomas Williams, Diana Hernandez, Thomas Watson, Vidya Ramathas, Simon Pitchford, Clive Page, Yen Choo

Marina Tarunina: Engineered Platelets From Human iPSCs Support Haemostasis Without Thromboembolism

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Abdullah Erikat Anna Kelis Cedric Humbert Clive Page Diana Hernandez Haemostasis Health Hematology Hemostasis Hemostasis News Hemostasis Today iPSCs Lam Lam Marina Tarunina Medicine Plasticell Richard Amison Shahzad Ali Simon Pitchford Tatyana Ponomaryov Thomas Watson Thomas Williams thromboembolism Thrombosis Research Vidya Ramathas Yen Choo
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