Noelia Grande Gutiérrez: Scale-Dependent Mechanisms of Near-Wall Platelet Enrichment in Arterial Flows
Noelia Grande Gutiérrez, Assistant Professor at Carnegie Mellon University, shared Biomedical Flows Simulation and Multiscale Modeling Lab’s post on LinkedIn:
“Excited to share this new work from our group!
This study is the first step toward building a comprehensive multiscale framework for arterial thrombosis modeling.
We aim to bridge platelet-scale transport physics with patient-specific arterial hemodynamics, enabling more accurate and personalized simulations.
More to come as we continue developing this framework for multiscale arterial thrombosis simulations.
Stay tuned!”
Biomedical Flows Simulation and Multiscale Modeling Lab shared a post on LinkedIn about a recent article by Arnav Garcha, published in Physics of Fluids, adding:
“New paper alert!
Our latest research paper, ‘Scale-dependent mechanisms of near-wall platelet enrichment in arterial flows,’ led by PhD student Arnav Garcha, has been published in Physics of Fluids, AIP Publishing.
This paper was selected as an Editor’s Pick!
In this study, we use computational modeling to investigate the mechanisms governing platelet transport and near-wall enrichment across vascular scales, aiming to clarify whether platelet margination persists in arterial flows.
- At the arteriole scale, red blood cell (RBC)-driven platelet margination leads to significant near-wall enrichment, highlighting the importance of incorporating hematocrit-enhanced drift in platelet transport models.
- At the arterial scale, RBC-driven margination becomes negligible, with platelet distributions remaining nearly uniform under axisymmetric flow conditions.
- In curved arterial geometries, secondary flows emerge as the dominant mechanism, driving cross-stream transport and increasing near-wall platelet concentration.
Together, these findings show that platelet transport is scale-dependent, with distinct physical mechanisms governing behavior in arterioles versus arteries.
This work provides important insights for computational thrombosis modeling, offering practical guidance on selecting appropriate transport models across vascular scales and enabling more accurate multiscale simulations of platelet dynamics.”
Title: Scale-dependent mechanisms of near-wall platelet enrichment in arterial flows
Authors: Arnav Garcha, Noelia Grande Gutiérrez
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