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Blood Advances Study: Preeclampsia Risk in Sickle Cell Disease
American Society of Hematology/LinkedIn
Oct 24, 2025, 10:22

Blood Advances Study: Preeclampsia Risk in Sickle Cell Disease

American Society of Hematology shared an inviting post on LinkedIn:

“In pregnant women with sickle cell disease, the risk of developing early-onset preeclampsia can be determined by measuring levels of a protein associated with placental function and development, according to research published today in Blood Advances.

Placental growth factor (PlGF) is a protein produced by the placenta that supports the development of blood vessels. Measuring PlGF levels can help assess the risk of preeclampsia, a potentially deadly pregnancy complication that usually arises after 20 weeks and is characterized by high blood pressure and protein in the urine.

Women with sickle cell disease are more than 2.4 times likely to develop preeclampsia during pregnancy when compared to women without this condition. This complication can inhibit growth of the fetus, result in premature birth, and is associated with stroke and potential organ damage in the mother.

New findings provide insight that may help clinicians to anticipate and mitigate adverse pregnancy outcomes.

Read more about this new study.”

Preeclampsia

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American Society of Hematology Blood Advances Study Blood Vessels Health Hemostasis Today Kinga Malinowski Medicine Placental growth factor PlGF Preeclampsia Pregnancy Complication Sickle Cell Disease thrombosis
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