Nicolas Hubacz: Visualizing Red Blood Cell Flow Through Zebrafish Capillaries
Nicolas Hubacz, Research and Clinical Products Business Development Manager at Magstim, shared a post on LinkedIn:
”Blood Flow in Action
This microscopic view captures erythrocytes (red blood cells) moving through the capillary network of a small fish’s caudal fin.
Scientific context:
Optical transparency — In species like zebrafish, the fin tissue is translucent, enabling direct visualization of vascular dynamics in vivo without surgical intervention.
Capillary architecture — These microvessels are typically 5–10 μm in diameter, allowing red blood cells to pass in single file, optimizing gas exchange and nutrient delivery.
Hemodynamic insights — Real-time imaging enables measurement of blood velocity, flow patterns, and vessel diameter changes under different physiological or experimental conditions.
Model system — The zebrafish vascular network is a widely used platform for studying angiogenesis, microcirculatory physiology, and the effects of genetic or pharmacological manipulations on blood flow.
Studying microcirculation in transparent model organisms bridges the gap between cellular biology and whole-organism physiology, providing insights relevant to cardiovascular research, developmental biology, and regenerative medicine.
Credit to Fabian J. Weston for the great video!”
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