Giordano Botta: VA and Allelica Partner on Clinical Study of PRS and PGx in Cardiovascular Prevention
Giordano Botta, CEO and Co-Founder of Allelica, shared a post on LinkedIn:
“We are proud to partner with the U.S. Department of Veterans Affairs, the largest integrated healthcare system in the United States, on a randomized clinical trial evaluating the impact of polygenic risk score (PRS) and pharmacogenomics (PGx) in routine care.
This comes at a pivotal moment, as the new 2026 ACC/AHA guidelines now include PRS as a risk enhancing factor.
The study will compare standard care with a genomic guided approach.
Patients in the intervention arm will receive the Allelica multi-ancestry PRS for coronary artery disease together with PGx testing for statin response, including SLCO1B1.
The objective is to assess whether integrating genetic risk and drug response can improve statin prescription, adherence, and ultimately cardiovascular outcomes.
We look forward to supporting this clinical trial, designed to generate prospective evidence on the clinical utility of integrating PRS and PGx into cardiovascular prevention, with the potential to inform implementation at scale across large healthcare systems.”
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