Sam Tsimikas: Uncovering a Modifiable Lp(a) Phenotype in Hypertriglyceridemia
Sam Tsimikas, Professor of Medicine at the University of California, San Diego, shared a post on X about a recent article by Lizhu Lin et al, published in JACC: Basic to Translational Science, adding:
“We have a new paper today that links Lp(a) with triglycerides in patients with moderate hypertriglyceridemia (TG 150-500).
Using our new methods we developed UC San Diego Cardiology.
Lp(a) becomes TG- and cholesterol-enriched.
ApoC-III inhibition reduced Lp(a)-TG and Lp(a)-C by approximately 60–70 percent without lowering Lp(a) particle number, revealing pharmacologically modifiable Lp(a) heterogeneity.
We now need to see how Lp(a)-C and Lp(a)-TG correlate with CV outcomes.”
Title: A Novel Triglyceride- and Cholesterol-Enriched Lipoprotein(a) Phenotype in Moderate Hypertriglyceridemia: Reversal by ApoC-III Inhibition
Authors: Lizhu Lin, Maiah N. Brush, C. Bradley Nelson, Veronica J. Alexander, Shuting Xia, Philip L.S.M. Gordts, Sotirios Tsimikas
Stay updated on all scientific advances with Hemostasis Today.
-
Sep 18, 2026, 13:22Christine Rabinak: Predictive Modeling for Individualized Unfractionated Heparin Dosing
-
Sep 18, 2026, 13:07Bastu Odoka: Principles of Pediatric Transfusion Dosing
-
Sep 18, 2026, 12:54David McIntosh: Plasma Therapies and the Unfinished Global Access Mission
-
Sep 18, 2026, 11:10R. Stephani Hellwege: Beyond LVEF Echocardiographic Assessment of Undifferentiated Shock
-
Sep 18, 2026, 06:48Gopal Patidar: Honoured to Contribute to the ASFA 2026 Guidelines for Therapeutic Apheresis
-
Sep 18, 2026, 05:48Julie Taylor: Navigating Tech Glitches to Deliver Engaging BBTS Presentation
-
Sep 18, 2026, 05:42Emma Copperwaite: BBTS Conference Presentation Highlights Power of Peer Support and Pushing Past Fear
-
Sep 18, 2026, 05:34Suhasini Sil: RGSSH Joins Mega Blood Donation Camp at Thyagaraj Stadium
-
Sep 18, 2026, 05:25Lisa Laun: Spleen Clears Activated Platelets to Limit Thrombosis and Inflammation