Ahmed Koriesh/LinkedIn
Oct 27, 2025, 05:47
Ahmed Koriesh on The Novel Approach in Use of Tenecteplase
Ahmed Koriesh, Director Hospital Neurology Service at Cleveland Clinic Florida, shared on LinkedIn:
”Beyond 24 Hours: Tenecteplase Pushes the Clock Further
Last month, we asked: “Are we there yet?”
Now — with the 2025 TNK 4.5–24h Meta-Analysis, the answer may be even closer.
1,278 patients from 4 RCTs (TNK 0.25 mg/kg vs standard care/placebo)
Imaging-based selection (DWI–FLAIR mismatch or CT/MR perfusion)
Results:
- Excellent outcome (mRS 0–1 at 90 days): 35.1% vs 28.9% (OR 1.34, p = 0.02)
- Recanalization: 46.6% vs 28.4% (OR 3.30, p = 0.001)
- No increase in sICH or mortality
- Greater benefit in patients without EVT access
Interpretation:
IV tenecteplase up to 24 hours after onset appears to be beneficial and safe when guided by advanced imaging.
Clinical Pearl:
- From 3 → 4.5 → 9 → 24 hours — thrombolysis is no longer just about time, but about tissue.
- The line continues to blur — and that’s a good thing for stroke patients.”
Stay updated with Hemostasis Today.
-
Oct 27, 2025, 05:47Ahmed Koriesh on The Novel Approach in Use of Tenecteplase
-
Oct 27, 2025, 04:42Louise Breslin: Exciting Results in The CRYPTICS Trial
-
Oct 26, 2025, 16:55ECTH 2025: 3 Unforgettable Days of Science and Shared Purpose
-
Oct 26, 2025, 16:35Ahmed Koriesh on Thrombolysis in Stroke Patients on DOACs
-
Oct 26, 2025, 15:39Lisa Murphy on Life After Stroke Sessions at WSC 2025
-
Oct 27, 2025, 08:01Acquired Hemophilia A (AHA) is Rare and Often Missed - RPTH Journal
-
Oct 27, 2025, 05:00Wolfgang Miesbach on WFH Guidelines Covering FDA/EMA-Approved AAV Gene Therapy for Hemophilia
-
Oct 26, 2025, 15:04Nita Radhakrishnan and Colleagues on Inherited Haematological Conditions
-
Oct 26, 2025, 14:55Anirban Sen Gupta on Biosynthetic Blood Surrogates Current State-of-Art
-
Oct 26, 2025, 12:24Jean Philippe Galanaud, Jean Pierre Laroch, and Marc Righini on Historical Treatments of DVT
-
Oct 25, 2025, 07:42Adithya Hande: India’s Silent Killer and a Scientific Breakthrough
-
Oct 23, 2025, 09:57Arun V. J: Artificial Blood Is Closer Than You Think
-
Oct 23, 2025, 07:11Sebastien Lobet Presented the ACTIVLIM-Hemo Scale
-
Oct 23, 2025, 07:05Syed Ehsan Shah on Advantages of Werfen HemoCell Automation
-
Oct 22, 2025, 08:25Johanna Nystedt: Not Every Day We Can Release a New Blood Product to Meet An Unmet Medical Need!
-
Oct 27, 2025, 08:00Rohit Gosain: Revumenib is Now FDA Approved for R/R AML with NPM1 Mutation
-
Oct 27, 2025, 06:30Andres Ricaurte Fajardo on CVT Experience from a Latin American Cohort
-
Oct 27, 2025, 05:15Love Preet Kalra: I Had The Pleasure of Meeting Future Leader Sarah Matuja
-
Oct 25, 2025, 09:32Sylaja Pn Wins 2025 WSO Presidential Award
-
Oct 25, 2025, 08:21Courtney Lawrence: Listen. Empower. Deliver. Save Lives!
Oct 27, 2025, 08:01
Oct 27, 2025, 08:00
Oct 27, 2025, 06:30
Oct 27, 2025, 05:47
Oct 27, 2025, 05:15
Oct 27, 2025, 04:42
Oct 26, 2025, 16:55
Oct 26, 2025, 16:35
Oct 26, 2025, 15:39
Oct 26, 2025, 15:04