Thierry Burnouf on Platelet-Derived Extracellular Vesicles and Their Role in Neurogenesis
Thierry Burnouf, Vice-Dean, Distinguished Professor, Biomedical Engineering at Taipei Medical University, shared on LinkedIn:
”New paper published in Biomaterials: “Platelet concentrate–derived extracellular vesicles promote adult hippocampal neurogenesis” by Ariunjargal Nyam-Erdene, Nhi Thao Ngoc Le, Ouada N.,Emilie Faivre, liling delila, Ming-Li Chou, Joshua Lowe, Kadiombo Bantubungi-Blum, Luc Buee, Luc Buee, Tara Walker, David Blum, and Thierry Burnouf.
DOI: 10.1016/j.biomaterials.2025.123838
This work is the result of a collaboration between Taipei Medical University, University of Lille-, and UQ Queensland Brain Institute.
Key messages of the paper:
(1) Demonstrates that the platelet concentrate–derived secretome enhances neurogenesis in the adult brain, which is a critical step toward clinical translation.
(2) Uses clinically-approved platelet concentrates as starting material, showing a realistic pathway for GMP-compatible, scalable production of the platelet secretome.
(3) Shows how expired or surplus platelet units from blood establishments can be transformed into high-value biotherapies, instead of being discarded.
(4) Combines expertise from TMU (platelet-derived products), ULille (neurodegenerative diseases), and QBI (adult neurogenesis and brain repair), exemplifying a model of translational, international collaboration.”
Read the full article here.
Article: Platelet concentrate-derived extracellular vesicles promote adult hippocampal neurogenesis
Authors: Ariunjargal NyamErdene, Nhi Thao Ngoc Le, Ouada Nebie, Emilie Faivre, Liling Delila, Ming-Li Chou, Joshua R. Lowe, Kadiombo Bantubungi, Luc Buée, Tara L. Walker, David Blum, Thierry Burnouf
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