Edina Cenko Shared STRIVE Trial – Intracoronary Alteplase Shows No Advantage in STEMI
Edina Cenko, Chairperson of ESC Working Group on Coronary Pathophysiology and Microcirculation, posted on LinkedIn:
”The STRIVE trial showed that intracoronary alteplase during primary PCI for STEMI with high thrombus burden did not improve MACE, ST-segment resolution or myocardial blush grade compared with placebo, with a signal toward more ventricular fibrillation.
Once more, no adjunctive strategy has yet succeeded in improving downstream microvascular perfusion after epicardial flow is restored. The search for an effective solution in MVO after STEMI continues.”
Read the study here.
Title: Intracoronary Low-Dose Recombinant Tissue Plasminogen Activator in Primary PCI for ST-Segment Elevation Myocardial Infarction and Large Thrombus Burden: A Randomized Trial
Authors: Shamir R. Mehta, Natalia Pinilla-Echeverri, Denise Tiong, Tanya Kovalova, Tej Sheth, Madhu K. Natarajan, Matthew Sibbald, James L. Velianou, Robert Welsh, Bryan Har, Sanjit S. Jolly, Nicholas Valettas, J.D. Schwalm, Michael Tsang, Rutaba Khatun, Rajibul Mian, Jennifer Cunningham, Eric Ly, Tara McCready, Kevin R. Bainey
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