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Preventing VTE in Cancer, Maintaining Low Bleeding Risk: Reduced-Dose Apixaban
Jul 13, 2025, 17:57

Preventing VTE in Cancer, Maintaining Low Bleeding Risk: Reduced-Dose Apixaban

Mario Balsa, medical oncology resident at Institut Català d’Oncologia, shared an insightful post on X:

” ‘New’ The New England Journal of Medicine (NEJM) study in 1,766 patients with cancer-associated VTE:

  • Reduced-dose apixaban (2.5mg BID) vs full dose (5mg BID)
  • VTE recurrence: 2.1% vs 2.8%
  • Clinically relevant bleeding: 12.1% vs 15.6%

Same protection, less bleeding. Sometimes, less really is more!”

Effects of reduced dose of an oral anticoagulant on thromboembolic events and bleeding are discussed in the new study ”Extended Reduced-Dose Apixaban for Cancer-Associated Venous Thromboembolism” published by Isabelle Mahé et al. in the New England Journal of Medicine (NEJM).

In patients with active cancer and venous thromboembolism, extended treatment with reduced-dose apixaban was as effective as the full dose in preventing recurrent events.

Moreover, dose reduction resulted in fewer bleeding complications.

This supports reduced-dose apixaban as a safer alternative for long-term anticoagulation in this population.

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cancer induced venous thromboembolism Health Hematology Hemostasis Today Isabelle Mahé Medicine NEJM Reduced-Dose Apixaban venous thromboembolism
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