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James Crowley: Fibrosis Can Be Caused by Mechanical Disruption of the Lymphatic Vessels Alone
James P. Crowley/www.researchgate.net
Mar 29, 2026, 16:14

James Crowley: Fibrosis Can Be Caused by Mechanical Disruption of the Lymphatic Vessels Alone

James Crowley, Professor of Medicine Emeritus at Brown University, Captain at U.S. Navy Reserve, shared a post on LinkedIn about a recent article by Hailey M. Shepherd et al, adding:

“Authors Kreisel and Shepherd from WashU emphasized that the research team conducted these transplants among genetically identical mice, whose tissues could not generate an immune response against one another.

This provides evidence that the fibrosis is independent of immunity against foreign tissues and instead can be caused by the mechanical disruption of the lymphatic vessels alone.

The treatment that blocked the protein responsible for manufacturing hyaluronan is called 4-methylumbelliferone (4-MU).

It is approved for use in Europe and Asia to treat biliary disorders, conditions that affect the gallbladder.

According to the researchers, it has an excellent safety profile and is therefore a promising potential route to evaluating this approach in transplant patients.”

Title: Lymphatic disruption drives lung transplant fibrosis through interleukin-1–mediated hyaluronan accumulation

Authors: Hailey M. Shepherd, Wenjun Li, Benjamin J. Kopecky, Yuriko Terada, Charles R. Liu, Zhiyi Liu, Daniel D. Lee, Katsutaka Mineura, Hao Dun, Yuhei Yokoyama, Brian W. Wong, Gokalp K. Kurtoglu, Junedh M. Amrute, Davide Scozzi, Yun Zhu Bai, Amit I. Bery, Cory T. Bernadt, Jon H. Ritter, Steven L. Brody, Derek E. Byers, Alexander S. Krupnick, Ruben G. Nava, G. Alexander Patterson, Varun Puri, Andrew E. Gelman, Kory J. Lavine, Gwendalyn J. Randolph, Daniel Kreisel

Read the Full Article on Science

James Crowley: Fibrosis Can Be Caused by Mechanical Disruption of the Lymphatic Vessels Alone

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Alexander S. Krupnick Amit I. Bery Andrew E. Gelman Benjamin J. Kopecky Brian W. Wong Charles R. Liu Cory T. Bernadt Daniel D. Lee Daniel Kreisel Davide Scozzi Derek E. Byers G. Alexander Patterson Gokalp K. Kurtoglu Gwendalyn J. Randolph Hailey M. Shepherd Hao Dun Health Hematology Hemostasis News Hemostasis Today Interleukin-1 James Crowley Jon H. Ritter Junedh M. Amrute Katsutaka Mineura Kory J. Lavine Lymphatic Drainage Medicine Ruben G. Nava Science Steven L. Brody Transplant Rejection Varun Puri WashU Wenjun Li Yuhei Yokoyama Yun Zhu Bai Yuriko Terada Zhiyi Liu
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