James Crowley: Fibrosis Can Be Caused by Mechanical Disruption of the Lymphatic Vessels Alone
James Crowley, Professor of Medicine Emeritus at Brown University, Captain at U.S. Navy Reserve, shared a post on LinkedIn about a recent article by Hailey M. Shepherd et al, adding:
“Authors Kreisel and Shepherd from WashU emphasized that the research team conducted these transplants among genetically identical mice, whose tissues could not generate an immune response against one another.
This provides evidence that the fibrosis is independent of immunity against foreign tissues and instead can be caused by the mechanical disruption of the lymphatic vessels alone.
The treatment that blocked the protein responsible for manufacturing hyaluronan is called 4-methylumbelliferone (4-MU).
It is approved for use in Europe and Asia to treat biliary disorders, conditions that affect the gallbladder.
According to the researchers, it has an excellent safety profile and is therefore a promising potential route to evaluating this approach in transplant patients.”
Title: Lymphatic disruption drives lung transplant fibrosis through interleukin-1–mediated hyaluronan accumulation
Authors: Hailey M. Shepherd, Wenjun Li, Benjamin J. Kopecky, Yuriko Terada, Charles R. Liu, Zhiyi Liu, Daniel D. Lee, Katsutaka Mineura, Hao Dun, Yuhei Yokoyama, Brian W. Wong, Gokalp K. Kurtoglu, Junedh M. Amrute, Davide Scozzi, Yun Zhu Bai, Amit I. Bery, Cory T. Bernadt, Jon H. Ritter, Steven L. Brody, Derek E. Byers, Alexander S. Krupnick, Ruben G. Nava, G. Alexander Patterson, Varun Puri, Andrew E. Gelman, Kory J. Lavine, Gwendalyn J. Randolph, Daniel Kreisel
Read the Full Article on Science
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