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Preeti Sinha: Molecular Mechanisms of Atherosclerosis
Preeti Sinha/LinkedIn
Apr 5, 2026, 05:32

Preeti Sinha: Molecular Mechanisms of Atherosclerosis

Preeti Sinha, Cardiologist in Gaya, Bihar, India, shared a post on LinkedIn:

“Understanding the Molecular Side of Atherosclerosis

Atherosclerosis is not just about cholesterol buildup – it’s a complex inflammatory process happening at the vascular level.

Recent insights highlight how endothelial dysfunction triggers a cascade of inflammatory signals, involving key pathways like p38 MAPK and NF-κB.

These pathways increase the expression of inflammatory markers such as TNF-α, IL-1β, VCAM1, and ICAM1, ultimately contributing to plaque formation and progression.

Interestingly, targeting regulators like VINAS (a long non-coding RNA) may help reduce vascular inflammation and slow down disease progression.

This opens new doors for precision therapies in cardiovascular care.

From gene expression to clinical outcomes – understanding these mechanisms helps us move closer to more targeted and effective treatments.

Prevention still remains key:

  • Control cholesterol
  • Manage blood pressure
  • Maintain a healthy lifestyle

Because every small step today protects your arteries tomorrow.”

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