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Shehab Mohamed: Thrombotic Complications in APL Are Not Rare and May Be Underrecognized
Shehab Mohamed,Honar Cherif/LinkedIn
Apr 21, 2026, 11:20

Shehab Mohamed: Thrombotic Complications in APL Are Not Rare and May Be Underrecognized

Shehab Mohamed, Hematologist at Hamad Medical Corporation, shared on LinkedIn about a recent article he and his colleagues co-authored, published in Clinical and Applied Thrombosis/Hemostasis, adding:

”New Publication | Acute Promyelocytic Leukemia (APL)

Excited to share our recent work:
‘Beyond Bleeding: Underrecognized Thrombotic Complications in Acute Promyelocytic Leukemia – A Single-Center Experience from the GCC Region’
Clinical and Applied Thrombosis/Hemostasis (2026)
PMID: 42007745

APL has long been viewed as a bleeding disorder.

But is that the full picture?

In our study, we highlight an often-overlooked aspect of APL:
Thrombotic complications are not rare – and may be underrecognized.

Key insights:

  • Thrombotic events occurred in a meaningful proportion of patients
  • Events were observed early, including at diagnosis and during induction therapy
  • Both venous and arterial thromboses were identified
  • APL represents a hemostatic paradox: simultaneous bleeding and thrombosis risk

Why this matters

These findings challenge the traditional perception of APL as purely hemorrhagic and emphasize the need for:

  • Increased clinical vigilance for thrombosis
  • Better risk stratification
  • Thoughtful consideration of management strategies during early treatment phases

From the GCC region, this study contributes important real-world data to a limited but growing body of literature on APL-associated thrombosis.

Special thanks to Honar Cherif for his valuable input and support.

Take-home message:
APL is not just about bleeding – thrombosis is an underrecognized and clinically relevant complication that deserves attention.”

Title: Beyond Bleeding: Underrecognized Thrombotic Complications in Acute Promyelocytic Leukemia — A Single-Center Experience from the GCC Region

Authors: Shehab Mohamed, Rafal AlShebly, Hawraa Shawaylia, Anil Elahie, Rola Ghasoub, Dina Soliman, Deen Mudawi, Mohammed Abdulgayoom, Abdulrahman Al-Mashdali, Maritta Rabadi, Hesham El-Sabah, Anas Hamad, Mohamed Yassin, Honar Cherif

Shehab Mohamed: Thrombotic Complications in APL Are Not Rare and May Be Underrecognized

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Acute Promyelocytic Leukemia aPL bleeding disorders Health Hematology Hemostasis Hemostasis News Hemostasis Today Medicine OncoDaily Shehab Mohamed thrombosis
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