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William Wallace: Why Vitamin C Is the Only Reason Your Collagen Doesn’t Melt at Body Temperature
William Wallace/X
May 11, 2026, 15:10

William Wallace: Why Vitamin C Is the Only Reason Your Collagen Doesn’t Melt at Body Temperature

William Wallace, Co-Founder and Chief Scientific Officer at Supplement Success Solutions, shared a post on LinkedIn about an article by Matthew D. Shoulders and Ronald T. Raines, adding:

“Your body makes collagen constantly.

But the version it assembles first isn’t finished.

Before collagen can hold its shape, an enzyme has to modify specific amino acids in the chain.

That enzyme needs vitamin C to work.

Here’s what vitamin C actually does:

it enables the chemical modification (hydroxylation) that allows three collagen chains to lock together into a stable triple helix.

Without that modification, the collagen structure is so weak it falls apart below body temperature.

Literally.

Unhydroxylated collagen melts at about 24°C.

Your body runs at 37°C.

The only thing keeping your collagen intact at body temperature is the modification that vitamin C makes possible.

This is why scurvy causes bleeding gums, loose teeth, poor wound healing, and joint pain.

Your body is still making collagen.

It just can’t hold together.
Vitamin C isn’t recycled in this process.

It’s consumed each time.

Your supply has to be continuously replenished.

Most collagen supplement studies co-administer vitamin C.

The ones that don’t rarely account for baseline vitamin C status.

If you’re taking collagen without adequate C, you’re supplying the raw material without the tool that finishes it.”

Title: Collagen Structure and Stability

Authors: Matthew D. Shoulders, Ronald T. Raines

William Wallace

 

 

Find more posts featuring William Wallace on Hemostasis Today.

Annu Rev Biochem Health Hematology Hemostasis Hemostasis News Hemostasis Today Matthew D. Shoulders Medicine Ronald T. Raines William Wallace
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