Genoveva Uzunova: Why It’s Time to Close the Sex Variable Gap in Healthcare
Genoveva Uzunova, Former Senior Staff Associate at Columbia University in the City of New York, shared a post on LinkedIn:
“Today marks Sex Diff Day and Mental Health Awareness Week – a perfect time to discuss a gap in our healthcare system:
Sex as a Biological Variable (SABV).
As both a psychiatrist and a genetherapy researcher, I’ve seen how ignoring sex differences, from brain stereotaxic coordinates in the lab to diagnostic scales in the psychiatry clinic, may lead to missed targets and missed diagnoses.
In this video, I explore why men’s depression often ‘masks’ as irritability, and why structural brain differences mean we must move toward truly precision psychiatry.
We cannot provide better care until we do better, sex-specific science.
We know that the brains of female mice have many neuroanatomical and gene expression differences with the brains of male mice, which may translate into different behaviors.
Diseases such as depression, anxiety, autism, Alzheimer’s disease, multiple sclerosis, Systemic lupus erythematosus (SLE), and breast cancer have higher rates in women than in men.
In connection with today, my dear Mom, Anelia Uzunova, published a letter in Nature in 1976 with her co-authors Estelle Ramey and Peter Ramwell, on the Effect of testosterone, sex and age on experimentally induced arterial thrombosis.
My views in this presentation are based on my professional experience and literature searches.
I have discussed many of them, particularly relating to gene therapy and depression, with my supervisors but have met with some resistance as this will complicate the studies and work.
When I researched brain gene therapies for neurodegenerative disorders, I measured the Bregma-Lambda distances in our four transgenic mouse strains and found differences between strains and males and females.”
Stay updated with Hemostasis Today.
-
May 13, 2026, 07:09Auston Cherbonneaux: Why Erythritol Just Joined the High-Hazard List
-
May 13, 2026, 06:48Akshat Jain: Transforming Sickle Cell Care With Practical Apheresis Frameworks
-
May 13, 2026, 06:35Dima Shulkin: How Neutrophil Extracellular Traps Shape ACS
-
May 13, 2026, 05:50Danny Hsu: Global Maternal VTE Awareness and Opportunities for Prevention
-
May 13, 2026, 05:50Ney Carter Borges: Clinical Cardiovascular Polygenic Risk Report for 8 Conditions
-
May 13, 2026, 05:49Kalyan Roy: A New Blood Group System Has Been Discovered
-
May 13, 2026, 05:07Azin Alizadehasl: Unraveling DIC in Cancer-Driven Coagulopathy
-
May 12, 2026, 16:46Tagreed Alkaltham: Why Apheresis Matters in Modern Transfusion Medicine
-
May 12, 2026, 16:37Reinhold Kreutz: Cardiovascular Burden in Acute Intermittent Porphyria Needs Greater Awareness