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Paolo Zamboni: How Female Steroid Metabolism Triggers Lipedema?
Paolo Zamboni/Canadian Neurovascular Health Society
May 27, 2026, 15:11

Paolo Zamboni: How Female Steroid Metabolism Triggers Lipedema?

Paolo Zamboni, Full Professor of Vascular Surgery at the University Hospital of Ferrara, shared a post on LinkedIn about a recent article by Daniil Vainberg et al., published in Veins and Lymphatics, adding:

“Lipedema is often misdiagnosed.

But even when a correct diagnosis is made, there’s a lot of embarrassment in explaining to a patient why she’s in that condition.

There is in general a lack of scientific information.

I’d like to point out an enlightening article that demonstrates how due to an aberrant enzyme activity, steroids from the normal female metabolism, can cause this condition.

The AKR1C1 variant decreases progesterone inactivation by 50%, leading to local progesterone accumulation and suppresses anti-adipogenic androgen signaling.

This leads to progressive adipose tissue hypertrophy.”

 

Title: From rare familial mutations to multifactorial disease: aldo-keto reductase 1C enzymes as a central biological pathway in lipedema

Authors: Daniil Vainberg, Jurgen Kaftalli, Luca Ferrari, Kristjana Dhuli, Beatrice Della Frera, Dominika Veselenyiova, Ahmad Jainul Abidin, SerenaPaolo Zamboni

Other posts featuring Paolo Zamboni on Hemostasis Today.

Ahmad Jainul Abidin Beatrice Della Frera Daniil Vainberg Dominika Veselenyiova Health Hematology Hemostasis Hemostasis News Hemostasis Today Jurgen Kaftalli Kristjana Dhuli Lipedema Luca Ferrari Matteo Bertelli Medicine Paolo Zamboni Sandro Michelni Serena Michelni Silvia Michelni
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