Ming Y Lim: The Burden and Impact of Bleeding in Newly Diagnosed Cancer Patients
Ming Y Lim, Clinical Associate Professor at the University of Utah, shared on LinkedIn about a recent article she and her colleagues co-authored, published in AJH, adding
”There is substantial focus on the prevention and management of cancer-associated thrombosis given its high prevalence and well-established impact on cancer outcomes.
However, as a hematologist, I am equally consulted for cancer-associated bleeding; an issue that is just as common but remains underrecognized by both oncologists and hematologists.
Notably, there is a paucity of data describing the incidence of bleeding in patients with newly diagnosed cancer, as most prior studies have focused on bleeding in the context of anticoagulation for cancer-associated thrombosis.
In this study, we analyzed over 2.4 million patients with newly diagnosed cancer across U.S. health systems.
We found that the cumulative incidence of clinically relevant bleeding (CRB) was 6.3% within the first year after cancer diagnosis.
Similar to thrombosis, the risk of CRB was higher among patients with advanced disease, greater comorbidity burden, recent hospitalizations, and those receiving systemic therapy.
Importantly, bleeding events were independently associated with increased mortality, particularly intracranial and gastrointestinal hemorrhage.
These findings highlight that bleeding risk in cancer patients is substantial and comparable in magnitude to thrombotic risk.
This underscores an urgent need for validated bleeding risk models that can be integrated alongside thrombosis prediction tools to guide safer, more personalized thromboprophylaxis strategies in cancer care.”
Title: Clinically Relevant Bleeding in Individuals With Cancer: Insights From a Nationwide Cohort Study
Authors: Ming Y. Lim, Radhika Gangaraju, Omid Jafari, Zihan Yang, Joyce W. T. Tiong, Elizabeth C. L. Chiang, Shengling Ma, Jun Y. Jiang, Justine Ryu, Barbara D. Lam, Mrinal Ranjan, Ang Li
Stay updated on all scientific advances with Hemostasis Today.
-
Jul 25, 2026, 18:00The Evolving Landscape of Factor Replacement Therapy – EAHAD
-
Jul 25, 2026, 17:43Heghine Khachatryan: Advancing Care for Women and Girls With Hemophilia
-
Jul 25, 2026, 17:00Revathy R Menon: A Memorable Milestone at the 39th ISBT Congress
-
Jul 25, 2026, 16:19Nicola Potere: From Scientific Exchange to Global Collaboration at ISTH 2026
-
Jul 25, 2026, 12:11Salma Abosabie: Honored to Have an Oral Presentation on Thromboinflammation at the ISTH 2026
-
Jul 25, 2026, 12:06Christina Hart: New Review on Coagulation Disorders in Philadelphia Chromosome-Negative MPNs
-
Jul 25, 2026, 11:57Leonard Valentino: Excited to Share The New Perspectives on Hemophilic Arthropathy
-
Jul 25, 2026, 11:49Meaghan O’Donnell: Highlighting Global Gaps in Haemophilia Carrier Registration at ISTH 2026
-
Jul 25, 2026, 11:43Emmanuel J Favaloro: Honored with the JTH Distinguished Peer Review Award