Heghine Khachatryan: The Inflammatory Engine Behind Venous Thrombosis
Heghine Khachatryan, Editor-in-Chief of Hemostasis Today, Head of Hemophilia and Thrombosis Center at Yeolyan Hematology and Oncology Center, shared Journal of Thrombosis and Haemostasis’ post on LinkedIn:
“Role of inflammation in venous thrombosis formation and resolution.
Venous thrombosis is increasingly recognized as a complex immunothrombotic process rather than a disorder driven solely by abnormalities of coagulation.
Accumulating evidence demonstrates that inflammation contributes substantially to thrombus initiation, propagation, and subsequent resolution.
Endothelial activation, leukocyte recruitment, cytokine release, platelet–immune cell interactions, and the formation of neutrophil extracellular traps (NETs) create a prothrombotic microenvironment that promotes clot formation and stabilization.
These mechanisms link innate immunity and hemostasis, highlighting the close interplay between inflammatory and coagulation pathways.
Inflammation, however, is not only involved in thrombus development.
It also plays a critical role in thrombus organization, recanalization, tissue repair, and restoration of venous function.
The balance between pro-inflammatory and reparative responses influences the efficiency of thrombus resolution and may determine the risk of long-term complications, including post-thrombotic syndrome.
A deeper understanding of the mechanisms connecting inflammation and thrombosis is reshaping contemporary concepts of venous thromboembolism and may pave the way for innovative therapeutic approaches that target both coagulation and inflammatory pathways.”
Journal of Thrombosis and Haemostasis (JTH) shared a post on LinkedIn about a recent article by Jennifer Le Mac et al, published in Journal of Thrombosis and Haemostasis, adding:
“Role of Inflammation in Venous Thrombosis Formation and Resolution.
This review highlights the critical role of immune cells — particularly monocytes — in VTE thrombus formation and resolution, proposing inflammation modulation as a promising complementary therapeutic strategy alongside anticoagulants.”
Title: Role of inflammation in venous thrombosis formation and resolution
Authors: Jennifer Le Mac, Mouhamed Bachir Ly, Catherine A. Lemarié
Stay updated on all scientific advances with Hemostasis Today.
-
Sep 25, 2026, 05:59Carla Lewis: Kids Conquering Sickle Disease Joins Nemours Children’s Hospital for 2nd Annual Awareness Event
-
Sep 25, 2026, 05:47Omid Seidizadeh: Evolutionary Constraint and Population Variation Across Coagulation Genes
-
Sep 25, 2026, 05:40Gerald Bertrand: Presenting UMi-NGS Non-Invasive Foetal HPA Genotyping at DGTI 2026
-
Sep 25, 2026, 05:33Urge Congress to support the Sickle Cell Disease Comprehensive Care Act – ASH
-
Sep 25, 2026, 05:24Isabelle Mahé: Reduced-Dose Apixaban in Extended CAT Treatment
-
Sep 25, 2026, 05:15Maria Cherska: High Cholesterol Isn’t Always Diet or Lifestyle – Sometimes It’s Genetic
-
Sep 25, 2026, 05:07Nancy Braithwaite: BBTS Specialist Certificate in Transfusion Science Practice
-
Sep 24, 2026, 18:43Hugh Nguyen: Honored to Accept the Friend of Singapore Red Cross Award
-
Sep 24, 2026, 18:42Titilope Fasipe: Proud to Support American Society of Hematology’s SCD Initiative