Mathis Richter: How The Bone Marrow Responds To Myocardial Infarction Predicts Clinical Outcome
Mathis Richter, PhD Student at University of Münster, shared a post on LinkedIn about a recent article he and his colleagues co-authored, published in Nature Cardiovascular Research, adding:
“Our new paper is out in Nature Cardiovascular Research
Under inflammatory stress, the bone marrow releases progressively less mature neutrophils into the blood, a phenomenon known for decades as the ‘left shift.’
We found that how deep this response goes is not random: it forms a graded continuum, and its deepest point, marked by circulating neutrophil progenitors, tracks with disease severity and survival in STEMI patients, alongside a coordinated inflammatory cytokine signature.
Bringing this question about basic neutrophil developmental biology to the clinic, we found that this deep mobilisation corresponds to a parameter already captured in routine blood counts.
These immature granulocytes (IGs) predicted early risk after STEMI, and in two independent clinical cohorts, patients with high IGs had a 6- to 8-fold higher risk of death within the first 30 days.
Grateful to the whole team and all collaborators who helped with this study!”
Title: Depth of neutrophil mobilization stratifies survival in ST-elevation myocardial infarction
Authors: Mathis Richter, Jessica von Göwels, Maximilian Fähndrich, Christian Lipgens Fernandez, Katharina Grohn, Marius Welzel, Dennis Schwarz, Alexander Lang, Amin Polzin, Sara Reinartz Groba, Luca Farinola, Susmita Ghosh, Jan-Niklas Heming, Hanna Aleth, Anastassia Akhalkatsi, Kian Marjani, Nicole Rübsamen, Tobias Radecke, Frank Rosenbauer, Albert Sickmann, André Karch, Alexander Zarbock, Jens Minnerup, Jürgen Sindermann, Alexander Bender, Jan Rossaint, Steffen Ormanns, Matthias Gunzer, Mariano Malamud, Rainer Kaiser, Kami Pekayvaz, Dominik Heider, Holger Reinecke, Lena Makowski, Christian Jung, Carlos Silvestre-Roig, Malte Kelm, Norbert Gerdes, Raphael Chevre, Stefan A. Lange, Oliver Soehnlein
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