Pall T. Onundarson: Real-World Evidence Challenges Routine DOAC Switching in Frail Older Adults with AF
Pall T. Onundarson, Professor Emeritus at Landspitali University Hospital, shared a post on LinkedIn:
”Frail elderly Korean atrial fibrillation patients do worse if switched to DOACs in a nationwide observational study.
This would appear to support the previous RCT of Joosten et al (Circulation. 2024;149:279–289. DOI: 10.1161/CIRCULATIONAHA.123.066485) from Holland.
It should also caution physicians against celebrating convenience over efficacy and safety if they are able to provide quality treatment with warfarin/VKAs.
It would also suggest that warfarin isn´t dead yet as treatment of NVAF – and that working on improved warfarin monitoring and outcomes remains worthwhile, even mandatory, for the benefit of patients.”
Title 1: To switch or not to switch: rethinking anticoagulation in frail elderly patients
Author: Paschalis Karakasis
Read the Full Article on European Heart Journal
Title 2: Reconsidering routine switching from warfarin to direct oral anticoagulants in frail elderly patients with atrial fibrillation stable on warfarin
Authors: So-Ryoung Lee, Eue-Keun Choi
Read the Full Article on European Heart Journal
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