ISBT on Age-Appropriate Platelet Transfusion Thresholds: New Insights from the 2025 AABB Guidelines
International Society of Blood Transfusion (ISBT) shared an enlightening post on LinkedIn:
“DID YOU KNOW? A new series by the Pediatric Subgroup of the Clinical Transfusion Working Party
In neonates, platelet transfusion thresholds are often higher than in adults due to immature hemostatic systems and a greater risk of bleeding.
Preterm infants may require platelet counts of 25,000–50,000/μL, depending on clinical condition, while stable adults typically require only 10,000–20,000/μL.
According to the 2025 AABB Guidelines, a restrictive threshold of 25,000/μL is now considered safer than the previously used liberal 50,000/μL threshold, which may increase risk.
This highlights the importance of age-appropriate transfusion strategies that reflect the unique physiology of neonates.
Reference: Metcalf RA, Nahirniak S, Guyatt G, et al. Platelet Transfusion: 2025 AABB and ICTMG International Clinical Practice Guidelines. JAMA. 2025. doi:10.1001/jama.2025.7529”
Find the reference here:
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